Hayes P C, Hussey A J, Keating J, Bouchier I A, Williams R, Beckett G J, Hayes J D
Department of Medicine, Ninewells Hospital and Medical School, Dundee, UK.
Clin Chim Acta. 1988 Mar 15;172(2-3):211-6. doi: 10.1016/0009-8981(88)90325-7.
Glutathione S-transferase (GST; EC 2.5.1.18), a sensitive marker of hepatocellular damage, was measured in patients on therapy for histologically proven, autoimmune chronic active hepatitis at various stages of the disease. GST levels were elevated in 65% of serum samples despite immuno-suppressive treatment compared with aspartate transaminase (AST) which was increased in only 23% of samples. In 55% of samples with normal AST concentrations, GST was elevated. No samples demonstrated abnormal transaminase with normal GST levels. It is concluded that continuing hepatocellular damage occurs in patients with autoimmune chronic active hepatitis on immuno-suppressive treatment.
