Steward Enosh Nirmalkumar, Patel Hiren, Pandya Haren, Dewan Hitesh, Bhavsar Bijal, Shah Urvi, Dholakia Kartik
Department of Oral & Maxillofacial Surgery, Faculty of Dental Science, Dharmsinh Desai University, Nadiad, Gujarat, India.
Ann Maxillofac Surg. 2020 Jul-Dec;10(2):409-416. doi: 10.4103/ams.ams_154_19. Epub 2020 Dec 23.
Plasma derivatives have been practiced a lot in orthopedics, burns, and sport medicine. Microneedling (MN) with platelet-rich plasma (PRP) therapy has been proven to improve the micro-circulation and thus improve hair growth. The role of concentrated growth factor (CGF) for hair growth has not been mentioned anywhere in the literature for hair growth which we tried to prove in our article by comparing it with various other studies.
This is a retrospective randomized study involving 20 male patients whose ages ranged from 21 years to 56 years. PRP was prepared using the dual-spin method and injected after activation; post-MN, CGF gel was applied topically. Four sessions were performed, and a follow-up was done after 6 months. Statistical analysis was done using the Statistical Package for the Social Sciences software version 21 for Windows (SPSS, IBM Corp, Armonk, NY, USA). Paired -test was used for the various comparisons.
Hair loss reduced by the end of the first month. At the end of 6 months, postfirst session, microscopic examination showed statistically significant difference in the hair count compared to those during the baseline.
PRP having platelet-derived growth factor and vascular endothelial growth factor acts on stem cells in the follicles, stimulating the development of new follicles and promoting neovascularization. CGF helps stimulating cell proliferation and matrix remodeling due to numerous growth factors in a concentrated form. Thus, this therapy combined helps to boost the hair growth in a very significant way.
This study provides the preliminary evidence of efficacy of PRP along with MN and CGF in treating androgenetic alopecia by promoting angiogenesis along with vascularization and promotes hair follicles to enter and extend the anagen phase. Most of the results obtained show improved results with this therapy. A larger case study for the same can further be done for a stronger recommendation of the use of CGF for hair growth therapy further.
血浆衍生物在骨科、烧伤科和运动医学中应用广泛。富含血小板血浆（PRP）微针疗法已被证明可改善微循环，从而促进头发生长。文献中未提及浓缩生长因子（CGF）对头发生长的作用，我们试图通过在本文中将其与其他各种研究进行比较来加以证明。
这是一项回顾性随机研究，涉及20名年龄在21岁至56岁之间的男性患者。采用双旋法制备PRP并在激活后注射；微针治疗后，局部应用CGF凝胶。共进行了四个疗程，并在6个月后进行随访。使用适用于Windows的社会科学统计软件包21版（SPSS，IBM公司，美国纽约州阿蒙克）进行统计分析。配对t检验用于各种比较。
第一个月末脱发减少。在第一个疗程结束6个月时，显微镜检查显示与基线期相比，毛发数量有统计学显著差异。
PRP含有血小板衍生生长因子和血管内皮生长因子，作用于毛囊中的干细胞，刺激新毛囊的发育并促进新血管形成。CGF由于浓缩形式的多种生长因子而有助于刺激细胞增殖和基质重塑。因此，这种联合疗法有助于显著促进头发生长。
本研究提供了初步证据，证明PRP联合微针和CGF通过促进血管生成和血管化来治疗雄激素性脱发，并促进毛囊进入并延长生长期。获得的大多数结果表明这种疗法效果良好。对于同一研究可进一步开展更大规模的病例研究，以便更有力地推荐将CGF用于头发生长治疗。
