Nie Han-Xiao, Zhang Ling, He Tao, Wang Li, Wan Bai-Shun, Wang Xiao-Qian, Han Feng
Department of Hepatopancreatobiliary Surgery, Henan Tumor Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Front Oncol. 2021 Feb 23;10:620550. doi: 10.3389/fonc.2020.620550. eCollection 2020.
Pancreatic cancer is a high incidence, high degree of malignancy, and high mortality in the digestive system tumor. The incidence of pancreatic cancer in China has increased nearly six folds in the past 20 years, ranking fifth in the mortality rate of malignant tumors, so it is particularly important to actively explore clinical indicators with better diagnostic significance for pancreatic cancer. LncRNA performs an essential regulatory function in the occurrence, development, and metastasis of many kinds of tumors, playing both a carcinogenic role and a tumor suppressor gene. Here, we demonstrated the function and mechanism of LncRNA-XLOC_012370 in the development of pancreatic cancer. In our research, the abnormal upregulation of XLOC_012370 was observed in pancreatic cancer patients' tumor tissues. XLOC_012370 was related to tumor stage, lymph node metastasis, and overall survival. Silencing of XLOC_012370 prevented the proliferation, migration, and invasion the NF-κB signal pathway. Further, miR-140-5p was identified as the target and downstream of XLOC_012370 and involved in pancreatic cancer progression. , knockdown of XLOC_012370 inhibited tumor growth the NF-κB signal pathway. In conclusion, lncRNA-XLOC_012370 is closely related to some malignant clinicopathological features and prognosis of pancreatic cancer. Thus the miR-140-5p/NF-κB signal pathway might represent a promising treatment strategy to combat pancreatic cancer.
胰腺癌是消化系统中发病率高、恶性程度高、死亡率高的肿瘤。在过去20年里，中国胰腺癌的发病率增长了近6倍，在恶性肿瘤死亡率中排名第五，因此积极探索对胰腺癌具有更好诊断意义的临床指标尤为重要。长链非编码RNA（lncRNA）在多种肿瘤的发生、发展和转移中发挥着重要的调节作用，兼具致癌作用和抑癌基因的功能。在此，我们阐述了lncRNA-XLOC_012370在胰腺癌发生发展中的功能及机制。在我们的研究中，观察到胰腺癌患者肿瘤组织中XLOC_012370异常上调。XLOC_012370与肿瘤分期、淋巴结转移及总生存期相关。沉默XLOC_012370可抑制胰腺癌细胞增殖、迁移和侵袭，其机制与NF-κB信号通路有关。此外，miR-140-5p被鉴定为XLOC_012370的靶标及下游分子，并参与胰腺癌进展。敲低XLOC_012370通过NF-κB信号通路抑制肿瘤生长。总之，lncRNA-XLOC_012370与胰腺癌的某些恶性临床病理特征及预后密切相关。因此，miR-140-5p/NF-κB信号通路可能是对抗胰腺癌的一种有前景的治疗策略。
