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长链非编码RNA XLOC_006390通过miR-296/ONECUT2轴调控人结直肠癌的增殖和转移

Long Noncoding XLOC_006390 Regulates the Proliferation and Metastasis of Human Colorectal Cancer via miR-296/ONECUT2 Axis.

作者信息

Ma Tianyi, Qiao Tianyu, Huang Rui, Wang Meng, Hu Hanqing, Yuan Ziming, Zhu Yihao, Wu Hongyu, Zou Xiaoming

机构信息

Department of Colorectal Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150001, China.

Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin150001, China.

出版信息

J Oncol. 2022 Jul 15;2022:4897201. doi: 10.1155/2022/4897201. eCollection 2022.

DOI:10.1155/2022/4897201
PMID:35874630
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9307412/
Abstract

Long noncoding RNA (LncRNA) XLOC_006390 has been shown to be dysregulated in cancer tissues and regulates cancer growth and development. Nonetheless, the molecular role of lncRNA-XLOC_006390 in colorectal cancer via modulation of miR-296/ONECUT2 axis is still unclear. Against this backdrop, the current study was designed to explore the role of lncRNA-XLOC_006390 in colorectal cancer proliferation and metastasis. The results revealed significant ( < 0.05) overexpression of lncRNA-XLOC_006390 in colorectal cancer tissues and cell lines, and the transcript levels increased with the advancement of the disease. Moreover, its high expression was shown to be associated with poor patient survival. Silencing of lncRNA-XLOC_006390 in colorectal cancer cells significantly ( < 0.05) suppressed their viability via onset of apoptosis and restricted cancer cell migration and invasion. tumor growth was significantly ( < 0.05) inhibited under lncRNA-XLOC_006390 repression. LncRNA-XLOC_006390 was shown to sponge the expression of miR-296-3p which in turn acted via post-transcriptional suppression of ONECUT 2 transcription factor to regulate the growth of colorectal cancer. Taken together, the results revealed the oncogenic role of lncRNA-XLOC_006390 in colorectal cancer via modulation of miR-296/ONECUT2 axis. The results also point towards its prognostic and therapeutic potential in the treatment of colorectal cancer.

摘要

长链非编码RNA（LncRNA）XLOC_006390已被证明在癌组织中表达失调，并调节癌症的生长和发展。尽管如此，lncRNA-XLOC_006390通过调节miR-296/ONECUT2轴在结直肠癌中的分子作用仍不清楚。在此背景下，本研究旨在探讨lncRNA-XLOC_006390在结直肠癌增殖和转移中的作用。结果显示，lncRNA-XLOC_006390在结直肠癌组织和细胞系中显著（<0.05）过表达，且转录水平随疾病进展而升高。此外，其高表达与患者预后不良相关。在结直肠癌细胞中沉默lncRNA-XLOC_006390可通过诱导凋亡显著（<0.05）抑制其活力，并限制癌细胞的迁移和侵袭。在lncRNA-XLOC_006390受到抑制的情况下，肿瘤生长显著（<0.05）受到抑制。lncRNA-XLOC_006390被证明可吸附miR-296-3p的表达，进而通过对ONECUT 2转录因子的转录后抑制作用来调节结直肠癌的生长。综上所述，结果揭示了lncRNA-XLOC_006390通过调节miR-296/ONECUT2轴在结直肠癌中的致癌作用。这些结果也表明了其在结直肠癌治疗中的预后和治疗潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/423d/9307412/aa298674496f/JO2022-4897201.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/423d/9307412/911d9a09388e/JO2022-4897201.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/423d/9307412/f80904c441b2/JO2022-4897201.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/423d/9307412/d799b21878cc/JO2022-4897201.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/423d/9307412/894329dd5e1f/JO2022-4897201.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/423d/9307412/30b27351d34f/JO2022-4897201.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/423d/9307412/aa298674496f/JO2022-4897201.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/423d/9307412/911d9a09388e/JO2022-4897201.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/423d/9307412/f80904c441b2/JO2022-4897201.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/423d/9307412/d799b21878cc/JO2022-4897201.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/423d/9307412/894329dd5e1f/JO2022-4897201.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/423d/9307412/30b27351d34f/JO2022-4897201.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/423d/9307412/aa298674496f/JO2022-4897201.006.jpg

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