伊朗西南部口腔扁平苔藓患者的血清维生素谱。
Serum Vitamin Profile in Oral Lichen Planus Patients in Southwest of Iran.
机构信息
Oral & Dental Disease Research Center, Department of Oral and Maxillofacial Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Student Research Committee, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
出版信息
Biomed Res Int. 2021 Feb 24;2021:8627435. doi: 10.1155/2021/8627435. eCollection 2021.
INTRODUCTION
Oral lichen planus (OLP) is a chronic mucocutaneous disease. It is mainly an immune system-related disorder. Vitamins can modulate immune system functions, and thus, vitamin deficiency might have roles in exacerbating OLP. We aim to determine the serum levels of vitamins A, B12, C, D3, and E in OLP patients.
METHODS AND MATERIALS
34 OLP patients referred to Shiraz Dental School entered the study. Blood samples were collected and levels of A, B12, C, D3, and E vitamins were measured in serum. 43 healthy people were also included as the control group. Serum levels of vitamins were measured by HPLC (A, B12, D3, and E) and Kiazist analyzing kit (vitamin C).
RESULTS
Most of the patients were female (62.3%), and the mean age of patients was 48.03 ± 11.57. Serum levels of vitamins A, C, and E were lower in OLP patients in comparison with the healthy group; however, the difference was not significant. Vitamins B12 and D3 were higher in the OLP group but the difference was not significant.
CONCLUSION
Serum levels of vitamins A, B12, C, D3, and E do not have a significant difference in OLP patients and healthy groups. These vitamins may not have a considerable role in OLP pathogenesis in the southwest of Iran.
简介
口腔扁平苔藓（OLP）是一种慢性黏膜疾病。它主要是一种与免疫系统相关的疾病。维生素可以调节免疫系统的功能，因此，维生素缺乏可能在加重 OLP 方面发挥作用。我们旨在确定 OLP 患者血清中维生素 A、B12、C、D3 和 E 的水平。
方法和材料
34 名转诊至设拉子牙科学院的 OLP 患者进入研究。采集血液样本并测量血清中维生素 A、B12、C、D3 和 E 的水平。还纳入了 43 名健康人作为对照组。使用 HPLC（A、B12、D3 和 E）和 Kiazist 分析试剂盒（维生素 C）测量血清维生素水平。
结果
大多数患者为女性（62.3%），患者的平均年龄为 48.03 ± 11.57 岁。与健康组相比，OLP 患者的血清维生素 A、C 和 E 水平较低；然而，差异无统计学意义。维生素 B12 和 D3 在 OLP 组中较高，但差异无统计学意义。
结论
OLP 患者和健康组的血清维生素 A、B12、C、D3 和 E 水平没有显著差异。在伊朗西南部，这些维生素在 OLP 发病机制中可能没有重要作用。
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