有症状的口腔扁平苔藓病例血清维生素B12水平降低：一项横断面研究。
Reduced levels of serum vitamin B12 in symptomatic cases of oral lichen planus: A cross-sectional study.
作者信息
Naik Shantala R, Gupta Prashant, Khaitan Tanya, Shukla Anjani Kumar
机构信息
Dept of Oral Medicine and Radiology, Dental Institute - Rajendra Institute of Medical Sciences, Ranchi, 834001, India.
出版信息
J Oral Biol Craniofac Res. 2020 Oct-Dec;10(4):578-582. doi: 10.1016/j.jobcr.2020.07.010. Epub 2020 Aug 21.
OBJECTIVES
Oral Lichen Planus OLP) is an immune mediated disease and causes oro-mucosal burning sensation that reduces food intake and hence resulting in nutritional deficiency. The present study was done to evaluate the serum levels of vitamin B12 in patients with symptomatic OLP and establish an association between reduced B12 levels and OLP.
MATERIALS AND METHOD
Serum vitamin B12 was assessed in 60 symptomatic cases of oral lichen planus and 60 healthy age and gender matched controls.
RESULTS
Serum vitamin B12 was significantly reduced (p value < 0) in patients with oral lichen planus when compared to healthy individuals. 43.33% of cases (26 out of 60) had B12 levels less than 187 pg/ml.
CONCLUSION
Oral lichen planus causes serum vitamin B12 deficiency. Vitamin B12 is linked with normal functioning of immune and neuropsychologic system which has a role to play in etiopathogenesis and malignant transformation of oral lichen planus.
目的
口腔扁平苔藓（OLP）是一种免疫介导性疾病，会引起口腔黏膜烧灼感，减少食物摄入量，进而导致营养缺乏。本研究旨在评估有症状的OLP患者血清维生素B12水平，并确定维生素B12水平降低与OLP之间的关联。
材料与方法
对60例有症状的口腔扁平苔藓患者和60例年龄、性别匹配的健康对照者进行血清维生素B12评估。
结果
与健康个体相比，口腔扁平苔藓患者的血清维生素B12水平显著降低（p值<0）。43.33%的病例（60例中的26例）维生素B12水平低于187 pg/ml。
结论
口腔扁平苔藓会导致血清维生素B12缺乏。维生素B12与免疫和神经心理系统的正常功能有关，在口腔扁平苔藓的病因发病机制和恶性转化中起作用。
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