Atkinson Irina
"Ilie Murgulescu" Institute of Physical Chemistry of the Romanian Academy, 202, Spl. Independentei, 060021 Bucharest, Romania.
Bioengineering (Basel). 2022 Sep 21;9(10):489. doi: 10.3390/bioengineering9100489.
One of the major clinical issues during the implantation procedure is the bacterial infections linked to biofilms. Due to their tissue localization and the type of bacteria involved, bacterial infections at implant sites are usually difficult to treat, which increases patient morbidity and even mortality. The difficulty of treating biofilm-associated infections and the emergence of multidrug-resistant bacteria are further challenges for the scientific community to develop novel biomaterials with excellent biocompatibility and antibacterial properties. Given their ability to stimulate bone formation and have antibacterial properties, metal ion-doped bioactive glasses (BGs) have received considerable research. This mini review aims to be successful in presenting the developments made about the role of biocide metal ions incorporated into BGs against the development of bacterial biofilms and the spread of nosocomial diseases.
植入过程中的一个主要临床问题是与生物膜相关的细菌感染。由于其组织定位和所涉及的细菌类型,植入部位的细菌感染通常难以治疗,这会增加患者的发病率甚至死亡率。治疗生物膜相关感染的困难以及多重耐药细菌的出现,是科学界开发具有优异生物相容性和抗菌性能的新型生物材料所面临的进一步挑战。鉴于其具有刺激骨形成和抗菌的特性,金属离子掺杂的生物活性玻璃(BGs)已受到大量研究。本综述旨在成功介绍关于掺入BGs中的杀菌金属离子在对抗细菌生物膜形成和医院感染传播方面所起作用的研究进展。