Department of Biomaterials, Institute of Clinical Dentistry, University of Oslo, 0317 Oslo, Norway.
Bioengineering Research Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center (MERC), Tehran 14155-4777, Iran.
ACS Biomater Sci Eng. 2020 Jan 13;6(1):4-20. doi: 10.1021/acsbiomaterials.8b01078. Epub 2019 Apr 22.
Over the past few decades, biomedical scientists and surgeons have given substantial attention to bioactive glasses as promising, long-lasting biomaterials that can make chemical connections with the neighboring hard and soft tissues. Several studies have examined the cellular and molecular responses to bioactive glasses to determine if they are suitable biomaterials for tissue engineering and regenerative medicine. In this regard, different ions and additives have been used recently to induce specific characteristics for selective cellular and molecular responses. This Review briefly describes foreign-body response mechanisms and the role of adsorbed proteins as the key players in starting interactions between cells and biomaterials. It then explains the physicochemical properties of the most common bioactive glasses, which have a significant impact on their cellular and molecular responses. It is expected that, with the development of novel strategies, the physiochemical properties of bioactive glasses can be engineered to precisely control proteins' adsorption and cellular functions after implantation.
在过去的几十年中，生物医学科学家和外科医生已经对生物活性玻璃给予了极大的关注，将其视为具有前景的、持久的生物材料，可以与相邻的硬组织和软组织进行化学连接。许多研究已经研究了生物活性玻璃的细胞和分子反应，以确定它们是否适合组织工程和再生医学的生物材料。在这方面，最近已经使用了不同的离子和添加剂来诱导特定的特性，以产生选择性的细胞和分子反应。本文简要描述了异物反应机制以及吸附蛋白的作用，这些蛋白是细胞与生物材料相互作用的关键因素。然后，本文解释了最常见的生物活性玻璃的物理化学性质，这些性质对其细胞和分子反应有重大影响。预计随着新策略的发展，可以对生物活性玻璃的物理化学性质进行工程设计，以精确控制植入后蛋白质的吸附和细胞功能。
