Cacioli D, Clivati A, Pelosi P, Megevand J, Galeone M
Second Surgical Division, Sesto S. Giovanni Hospital, Milan, Italy.
Curr Med Res Opin. 1988;10(10):668-74. doi: 10.1185/03007998809111117.
A prospective, single-blind study was carried out in 30 patients with obstructive peripheral artery disease to investigate the haemorheological properties of fructose-1,6-diphosphate (FDP). Patients were allocated at random to receive 7 to 10-days' treatment with either 10 g or 10% FDP twice daily or saline. Measurements were made on entry and at the end of treatment of whole blood and plasma viscosity, erythrocyte deformability and aggregation, and lower limb blood flow was evaluated by Doppler technique. FDP treatment was associated with a reduction in whole blood viscosity (24%) and red blood cell aggregation index (27%), and an improvement in red blood cell deformability (42%) (p less than 0.01). No significant changes were observed in the control group. Plasma viscosity did not change in either treatment group. Limb blood flow increased (p less than 0.05) only in patients treated with FDP; the improvement was more pronounced in the most severely affected side (30%). No untoward events were observed or reported in any of the patients studied.
对30例阻塞性外周动脉疾病患者进行了一项前瞻性单盲研究，以调查1,6 - 二磷酸果糖（FDP）的血液流变学特性。患者被随机分配，接受为期7至10天的治疗，每日两次，每次分别给予10 g或10%的FDP或生理盐水。在入组时和治疗结束时测量全血和血浆粘度、红细胞变形性和聚集性，并通过多普勒技术评估下肢血流。FDP治疗使全血粘度降低了24%，红细胞聚集指数降低了27%，红细胞变形性提高了42%（p < 0.01）。对照组未观察到显著变化。两个治疗组的血浆粘度均未改变。仅接受FDP治疗的患者肢体血流增加（p < 0.05）；在受影响最严重的一侧改善更为明显（30%）。在所研究的任何患者中均未观察到或报告不良事件。
