Perego M A, Sergio G, Espureo M, Francisci A, Artale F
Curr Med Res Opin. 1982;8(3):178-87. doi: 10.1185/03007998209112380.
The haemodynamic and haemorheological effects of buflomedil after acute intravenous infusion and after chronic treatment were studied in 25 patients with occlusive arterial diseases of the lower limbs. Acute treatment (100 mg) induced an increase in ankle blood pressure and in peripheral blood velocity, mainly of the continuous flow, as well as a significant decrease in blood viscosity and a significant increase (p less than 0.01) in red cell deformability, expressed as erythrocyte filtration flow. Chronic treatment (200 mg/day for 20 days) showed haemodynamic and haemorheological effects similar to those of the acute infusion, with a highly significant increase (p less than 0.001) in the erythrocyte flow at the end of the treatment period.
对25例下肢闭塞性动脉疾病患者研究了急性静脉输注和慢性治疗后丁咯地尔的血流动力学和血液流变学效应。急性治疗（100毫克）可使踝部血压升高、外周血流速度增加，主要是连续血流速度增加，同时血液粘度显著降低，红细胞变形能力显著增强（以红细胞滤过率表示，p<0.01）。慢性治疗（200毫克/天，共20天）显示出与急性输注相似的血流动力学和血液流变学效应，治疗期末红细胞流速显著增加（p<0.001）。
