State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
University of Science and Technology of China, Hefei, 230026, China.
Adv Mater. 2021 May;33(18):e2100333. doi: 10.1002/adma.202100333. Epub 2021 Apr 1.
The development of highly efficient, multifunctional, and biocompatible sonosensitizer is still a priority for current sonodynamic therapy (SDT). Herein, a defect-rich Ti-based metal-organic framework (MOF) (D-MOF(Ti)) with greatly improved sonosensitizing effect is simply constructed and used for enhanced SDT. Compared with the commonly used sonosensitizer TiO , D-MOF(Ti) results in a superior reactive oxygen species (ROS) yield under ultrasound (US) irradiation due to its narrow bandgap, which principally improves the US-triggered electron-hole separation. Meanwhile, due to the existence of Ti ions, D-MOF(Ti) also exhibits a high level of Fenton-like activity to enable chemodynamic therapy. Particularly, US as the excitation source of SDT can simultaneously enhance the Fenton-like reaction to achieve remarkably synergistic outcomes for oncotherapy. More importantly, D-MOF(Ti) can be degraded and metabolized out of the body after completion of its therapeutic functions without off-target toxicity. Overall, this work identifies a novel Ti-familial sonosensitizer harboring great potential for synergistic sonodynamic and chemodynamic cancer therapy.
高效、多功能且生物相容的声敏剂的开发仍然是当前声动力疗法（SDT）的重点。在此，我们简单构建了一种富含缺陷的基于钛的金属-有机骨架（MOF）（D-MOF（Ti）），其声敏化效果得到了极大改善，可用于增强 SDT。与常用的声敏剂 TiO2 相比，由于 D-MOF（Ti）的带隙较窄，在超声（US）照射下会产生更高的活性氧（ROS）产率，这主要提高了超声触发的电子-空穴分离。同时，由于 Ti 离子的存在，D-MOF（Ti）还表现出类芬顿活性，能够进行化学动力学治疗。特别地，US 作为 SDT 的激发源可以同时增强类芬顿反应，从而实现肿瘤治疗的显著协同效果。更重要的是，D-MOF（Ti）在完成治疗功能后可以被降解并代谢出体外，而不会产生脱靶毒性。总的来说，这项工作确定了一种新型的含钛声敏剂，具有协同声动力和化学动力学癌症治疗的巨大潜力。
