Wang Dianwei, Lin Lin, Li Tong, Meng Meng, Hao Kai, Guo Zhaopei, Chen Jie, Tian Huayu, Chen Xuesi
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
University of Science and Technology of China, Hefei, 230026, China.
Adv Mater. 2022 Nov;34(45):e2205924. doi: 10.1002/adma.202205924. Epub 2022 Oct 17.
To improve the therapeutic effect of sonodynamic therapy (SDT), more effective and stable sonosensitizers and therapeutic strategies are still required. A covalent organic framework (COF) sonosensitizer is developed by using a new nanoscale COF preparation strategy. This strategy uses molecular etching based on the imine exchange reaction to etch the bulk COF into nanoparticles and has universal applicability to imine-bond-based COF. The regular COF structure can prevent the loss of sonodynamic performance caused by the aggregation of porphyrin molecules and improve the chemical stability of the porphyrin unit. In addition, the coordination of Fe to COF endows the nanoparticle with chemodynamic therapy performance and glutathione consumption ability. The combination of enhanced SDT and α-PD-L1 antibody achieves a good antitumor effect. The innovative nanoscale COF sonosensitizer preparation strategy provides a new avenue for clinical antitumor therapy.
为提高声动力疗法（SDT）的治疗效果，仍需要更有效和稳定的声敏剂及治疗策略。通过一种新的纳米级共价有机框架（COF）制备策略开发了一种COF声敏剂。该策略利用基于亚胺交换反应的分子蚀刻将块状COF蚀刻成纳米颗粒，并且对基于亚胺键的COF具有普遍适用性。规则的COF结构可以防止卟啉分子聚集导致的声动力性能损失，并提高卟啉单元的化学稳定性。此外，Fe与COF的配位赋予纳米颗粒化学动力治疗性能和谷胱甘肽消耗能力。增强型SDT与α-PD-L1抗体的联合使用实现了良好的抗肿瘤效果。创新的纳米级COF声敏剂制备策略为临床抗肿瘤治疗提供了一条新途径。
