Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Istanbul Sabahattin Zaim University, Istanbul, Turkey.
Department of Histology and Embryology, School of Medicine, University of Yeditepe, Istanbul, Turkey.
J Trace Elem Med Biol. 2021 Jul;66:126736. doi: 10.1016/j.jtemb.2021.126736. Epub 2021 Mar 6.
Obesity is one of the most popular topic in the field of research. In order to defeat this highly widespread disease, the mechanism of fat accumulation at the molecular level and its elimination are crucial. The use of boron has been showing promising results during the recent years.
In this study, anti-obesity potential of Sodium Pentaborate Pentahydrate (SPP) used as a dietary supplement on BALB/c mice fed with a high-fat diet was evaluated. Mice were divided into four groups with different diets, consisting of a normal diet, a high-fat diet (HFD) (containing 60 % fat), a HFD-supplemented with 0.5 mg/g body weight (BW) of SPP and a HFD-supplemented with 1.5 mg/g body weight (BW) of SPP. The animals were then observed for 10 weeks and physically monitored, and were sacrificed at the end of the experiment for physical and physicochemical evaluation.
According to the physical parameters measured -body weight, food and water intake ratios-, the results indicate that SPP decreased weight gain in a dose dependent manner. Measurement of the hormone levels in the blood and fat accumulation in organs of mice also supported the anti-obesity effects of SPP. Expressions of adipogenesis related genes were also negatively regulated by SPP administration in white adipose tissue (WAT) tissue.
These findings promise a treatment approach and drug development that can be used against obesity when SPP is used in the right doses. As a future aspect, clinical studies with SPP will reveal the effect of boron derivatives on obesity.
肥胖是研究领域中最热门的话题之一。为了战胜这种高度普遍的疾病，脂肪在分子水平上的积累机制及其消除至关重要。近年来，硼的应用一直显示出很有前景的结果。
在这项研究中，评估了作为膳食补充剂的五硼酸钠五水合物（SPP）对高脂肪饮食喂养的 BALB/c 小鼠的抗肥胖潜力。将小鼠分为四组，分别给予不同的饮食，包括正常饮食、高脂肪饮食（HFD）（含 60%脂肪）、HFD 补充 0.5mg/g 体重（BW）的 SPP 和 HFD 补充 1.5mg/g 体重（BW）的 SPP。然后观察动物 10 周并进行物理监测，实验结束时对动物进行物理和物理化学评估后处死。
根据测量的生理参数-体重、食物和水的摄入比-，结果表明 SPP 以剂量依赖的方式降低了体重增加。测量血液中的激素水平和小鼠器官中的脂肪积累也支持了 SPP 的抗肥胖作用。SPP 给药还负调控白色脂肪组织（WAT）中脂肪生成相关基因的表达。
这些发现为肥胖症的治疗方法和药物开发提供了一种前景，当 SPP 以正确剂量使用时，可能会对抗肥胖症。作为未来的一个方面，SPP 的临床研究将揭示硼衍生物对肥胖症的影响。
