Cambridge Institute for Medical Research, Cambridge Biomedical Campus, University of Cambridge, Cambridge, CB2 0XY UK.
Cambridge Institute for Medical Research, Cambridge Biomedical Campus, University of Cambridge, Cambridge, CB2 0XY UK.
Curr Opin Cell Biol. 2021 Aug;71:87-94. doi: 10.1016/j.ceb.2021.02.008. Epub 2021 Mar 9.
The immune synapse is a very important but often transient site for secretion between immune cells. How secretion is controlled in a coordinated fashion at the synapse is a subject of much investigation. Two key mechanisms are the polarisation of the centrosome and rapid actin dynamics across the immune synapses that form between interacting immune cells. In recent years it has become clear that different immune cells utilise a diversity of immune synapses that modify these mechanisms in order to optimise specialised modes of secretion. Here we describe some of the latest research, focusing on regulation by centrosomal and actin dynamics in a variety of immune cells.
免疫突触是免疫细胞之间分泌的一个非常重要但通常是短暂的位点。在突触中如何协调控制分泌是一个研究的热点。两个关键机制是中心体的极化和在相互作用的免疫细胞之间形成的免疫突触中快速的肌动蛋白动态变化。近年来，人们已经清楚地认识到不同的免疫细胞利用各种免疫突触来修饰这些机制，以优化专门的分泌模式。在这里，我们描述了一些最新的研究，重点介绍了各种免疫细胞中中心体和肌动蛋白动力学的调节。
