Institute of Polymers, Composites and Biomaterials - National Research Council (IPCB-CNR), Mostra d'Oltremare pad.20 - Viale J.F. Kennedy 54, 80125, Naples, Italy.
Institute of Chemistry of Organometallic Compounds - National Research Council (ICCOM-CNR), Via Madonna del Piano 10, 50019, Sesto Fiorentino, Italy.
Sci Rep. 2021 Mar 12;11(1):5856. doi: 10.1038/s41598-021-85310-6.
Nowadays, prostate cancer is the most widespread tumour in worldwide male population. Actually, brachytherapy is the most advanced radiotherapy strategy for the local treatment of prostate cancer. It consists in the placing of radioactive sources closed to the tumour side thus killing cancer cells. However, brachytherapy causes the same adverse effects of external-beam radiotherapy. Therefore, alternative treatment approaches are required for enhancing radiotherapy effectiveness and reducing toxic symptoms. Nanostructured exfoliated black phosphorus (2D BP) may represent a strategic tool for local cancer therapy because of its capability to induce singlet oxygen production and act as photosensitizer. Hence, we investigated 2D BP in vitro effect on healthy and cancer prostate cell behavior. 2D BP was obtained through liquid exfoliation. 2D BP effect on healthy and cancer prostate cell behaviors was analyzed by investigating cell viability, oxidative stress and inflammatory marker expression. 2D BP inhibited prostate cancer cell survival, meanwhile promoted healthy prostate cell survival in vitro by modulating oxidative stress and immune response with and without near-infrared light (NIR)-irradiation. Nanostructured 2D BP is able to inhibit in vitro prostate cancer cells survival and preserve healthy prostate cell vitality through the control of oxidative stress and immune response, respectively.
如今，前列腺癌是全球男性人群中最普遍的肿瘤。实际上，近距离放射疗法是前列腺癌局部治疗中最先进的放射治疗策略。它包括将放射性源放置在靠近肿瘤的一侧，从而杀死癌细胞。然而，近距离放射疗法会引起与外部束放射治疗相同的不良反应。因此，需要替代治疗方法来提高放射治疗的效果并减轻毒性症状。纳米结构剥离黑磷（2D BP）因其能够诱导单线态氧的产生并作为光敏剂而可能成为局部癌症治疗的一种策略性工具。因此，我们研究了 2D BP 对健康和前列腺癌细胞行为的体外影响。通过液相剥离获得 2D BP。通过研究细胞活力、氧化应激和炎症标志物的表达来分析 2D BP 对健康和前列腺癌细胞行为的影响。2D BP 通过调节氧化应激和免疫反应，在体外抑制前列腺癌细胞的存活，同时促进健康前列腺细胞的存活，无论是否进行近红外光（NIR）照射。纳米结构的 2D BP 能够通过控制氧化应激和免疫反应，分别抑制体外前列腺癌细胞的存活并保持健康前列腺细胞的活力。
