调节性 T 细胞在结核分枝杆菌、鸟分枝杆菌和脓肿分枝杆菌感染中的双刃剑作用。
The double-edged sword of Tregs in M tuberculosis, M avium, and M absessus infection.
机构信息
Mycobacteria Research Laboratory, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, USA.
Department of Medicine, Rocky Mountain Regional Veterans Affairs Medical Center, Denver, CO, USA.
出版信息
Immunol Rev. 2021 May;301(1):48-61. doi: 10.1111/imr.12959. Epub 2021 Mar 12.
Abstract
Immunity against different Mycobacteria species targeting the lung requires distinctly different pulmonary immune responses for bacterial clearance. Many parameters of acquired and regulatory immune responses differ quantitatively and qualitatively from immunity during infection with Mycobacteria species. Nontuberculosis Mycobacteria species (NTM) Mycobacterium avium- (M avium), Mycobacterium abscessus-(M abscessus), and the Mycobacteria species Mycobacterium tuberculosis-(Mtb). Herein, we discuss the potential implications of acquired and regulatory immune responses in the context of animal and human studies, as well as future directions for efforts to treat Mycobacteria diseases.
摘要
针对肺部的不同分枝杆菌物种的免疫需要明显不同的肺部免疫反应来清除细菌。获得性和调节性免疫反应的许多参数在数量和质量上都与分枝杆菌物种感染期间的免疫反应不同。非结核分枝杆菌物种（NTM），如鸟分枝杆菌（M avium）、脓肿分枝杆菌（M abscessus）和结核分枝杆菌（Mtb）。在此，我们讨论了获得性和调节性免疫反应在动物和人类研究中的潜在意义，以及治疗分枝杆菌疾病的努力的未来方向。
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