Department of Chemistry, A. P. Nelubin Institute of Pharmacy, I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
Department of Pharmaceutical Technology, A. P. Nelubin Institute of Pharmacy, I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
Bull Exp Biol Med. 2021 Feb;170(4):444-447. doi: 10.1007/s10517-021-05083-w. Epub 2021 Mar 13.
Wound-healing activity of the crystalline form of dihydroquercetin and its microtubular pseudopolymorphic modification obtained by crystal engineering was compared using the rat model of IIIA degree burn. The rate of wound healing in the group treated with microtubular pseudopolymorphic modification of dihydroquercetin was 4.8±0.1%, which was higher by 11.6% than in the group treated with crystalline form (4.3±0.1%). Bioavailability analysis on MDCK cell culture showed that the apparent permeability coefficient of microtubular pseudopolymorphic modification was higher than that of crystalline form by 31.1% (19.4±0.2×10 and 14.8±0.3×10 cm/sec, respectively). It was proven that the use of crystal engineering improved the biopharmaceutical parameters of dihydroquercetin and increased its pharmacological efficiency.
采用晶体工程技术，比较了二氢槲皮素的结晶形式及其微管假多晶型修饰物的创伤愈合活性，该修饰物是通过晶体工程技术获得的。在 IIIA 度烧伤大鼠模型中比较了两种物质的疗效。用微管假多晶型修饰物治疗的组的伤口愈合率为 4.8±0.1%，比用结晶形式治疗的组（4.3±0.1%）高 11.6%。在 MDCK 细胞培养中的生物利用度分析表明，微管假多晶型修饰物的表观渗透系数比结晶形式高 31.1%（分别为 19.4±0.2×10 和 14.8±0.3×10 cm/sec）。证明使用晶体工程技术改善了二氢槲皮素的生物制药参数，并提高了其药理效率。
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