球形二氢槲皮素对链脲佐菌素诱导的糖尿病大鼠的保护作用。

Protective Properties of Spheroidal Taxifolin Form in Streptozotocin-Induced Diabetic Rats.

机构信息

Laboratory of Nanobiotechnology, Institute of Biomedical Chemistry, Pogodinskaya Str. 10/8, 119121 Moscow, Russia.

Nelubin Institute of Pharmacy, Sechenov First Moscow State Medical University, Trubetskaya Str. 8/2, 119991 Moscow, Russia.

出版信息

Int J Mol Sci. 2023 Jul 26;24(15):11962. doi: 10.3390/ijms241511962.

One of the key factors in the pathogenesis of diabetes and its complications is oxidative stress. To inhibit this process, antioxidants may be helpful. Herein, we focused on the protective properties of taxifolin spheroidal form (TS) in the streptozotocin rat model of diabetes mellitus. After 4 weeks of treatment with TS, the fasting blood glucose level of the diabetic animals decreased by 12% compared with the level right after the injection of streptozotocin. While the feed intake in the untreated diabetic rats increased by 5.3% compared with the healthy group, the TS-treated group showed a pronounced 15.3% decrease. Therapeutic administration of TS has a protective effect on the pancreas and the liver against the cytotoxic action of streptozotocin. The plasma antioxidant capacity of all diabetic groups appeared to be approximately 15% lower than in healthy rats with no significant difference between the TS-treated and untreated diabetic animals. Apparently, this can be attributed to taxifolin and plasma proteins binding. These data demonstrate the potential of TS in antidiabetic therapy.

糖尿病及其并发症发病机制的一个关键因素是氧化应激。为了抑制这个过程，抗氧化剂可能会有帮助。在此，我们专注于栎精球形体（TS）在链脲佐菌素诱导的糖尿病大鼠模型中的保护特性。经过 4 周的 TS 治疗，糖尿病动物的空腹血糖水平比链脲佐菌素注射后立即降低了 12%。虽然未经治疗的糖尿病大鼠的饲料摄入量比健康组增加了 5.3%，但 TS 治疗组的摄入量却明显下降了 15.3%。TS 的治疗给药对胰腺和肝脏具有对抗链脲佐菌素细胞毒性的保护作用。所有糖尿病组的血浆抗氧化能力似乎比健康大鼠低约 15%，但 TS 治疗组和未治疗的糖尿病动物之间没有显著差异。显然，这可以归因于栎精与血浆蛋白的结合。这些数据表明了 TS 在抗糖尿病治疗中的潜力。