Omelyanovskiy Vitaly, Musina Nuriya, Ratushnyak Svetlana, Bezdenezhnykh Tatiana, Fediaeva Vlada, Roudijk Bram, Purba Fredrick Dermawan
Center of Healthcare Quality Assessment and Control, Ministry of Health of the Russian Federation, Moscow, Russia.
Financial Research Institute at the Ministry of Finances of the Russian Federation, Moscow, Russia.
Qual Life Res. 2021 Jul;30(7):1997-2007. doi: 10.1007/s11136-021-02804-6. Epub 2021 Mar 13.
The most widely used generic questionnaire to estimate the quality of life for yielding quality-adjusted life years in economic evaluations is EQ-5D. Country-specific population value sets are required to use EQ-5D in economic evaluations. The aim of this study was to establish an EQ-5D-3L value set for Russia.
A representative sample aged 18+ years was recruited from the Russia`s general population. Computer-assisted face-to-face interviews were conducted based on the standardized valuation protocol using EQ-Portable Valuation Technology. Population preferences were elicited utilizing both composite time trade-off (cTTO) and discrete choice experiment (DCE) techniques. To estimate the value set, a hybrid regression model combining cTTO and DCE data was used.
A total of 300 respondents who successfully completed the interview were included in the primary analysis. 120 (40.0%) respondents reported no health problems of any dimension, and 56 (18.7%) reported moderate health problems in one dimension of the EQ-5D-3L. Median self-rated health using EQ-VAS was 80 with IQR 70-90. Comparing cTTO and DCE-predicted values for 243 health states resulted in a similar pattern. This supports the use of hybrid models. The predicted value based on the preferred model for the worst health state "33333" was -0.503. Mobility dimension had the most significant impact on the utility decrement, and anxiety/depression had the lowest decrement.
Determining a Russian national value set may be considered the first step towards promoting cost-utility analysis use to increase comparability among studies and improve the transferability of healthcare decision-making in Russia.
在经济评估中用于估算产生质量调整生命年的生活质量的最广泛使用的通用问卷是EQ-5D。在经济评估中使用EQ-5D需要特定国家的人群价值集。本研究的目的是为俄罗斯建立一个EQ-5D-3L价值集。
从俄罗斯普通人群中招募了年龄在18岁及以上的代表性样本。基于标准化评估协议，使用EQ便携式评估技术进行计算机辅助面对面访谈。利用复合时间权衡（cTTO）和离散选择实验（DCE）技术来获取人群偏好。为了估计价值集，使用了结合cTTO和DCE数据的混合回归模型。
共有300名成功完成访谈的受访者被纳入初步分析。120名（40.0%）受访者报告在任何维度上都没有健康问题，56名（18.7%）受访者报告在EQ-5D-3L的一个维度上存在中度健康问题。使用EQ-VAS自评健康的中位数为80，四分位间距为70-90。比较243种健康状态的cTTO和DCE预测值，结果呈现出相似的模式。这支持了混合模型的使用。基于首选模型对最差健康状态“33333”的预测值为-0.503。行动能力维度对效用降低的影响最大，焦虑/抑郁维度的降低最小。
确定俄罗斯国家价值集可被视为朝着促进成本效用分析的应用迈出的第一步，以提高研究之间的可比性，并改善俄罗斯医疗保健决策的可转移性。
