Al Rabayah Abeer, Roudijk Bram, Purba Fredrick Dermawan, Rencz Fanni, Jaddoua Saad, Siebert Uwe
Institute of Public Health, Medical Decision Making and Health Technology Assessment, Department of Public Health, Health Services Research, and Health Technology Assessment, UMIT TIROL - University for Health Sciences and Technology, Hall in Tirol, Austria.
Center for Drug Policy and Technology Assessment, Pharmacy Department, King Hussein Cancer Center, Amman, Jordan.
Eur J Health Econ. 2025 Apr;26(3):487-501. doi: 10.1007/s10198-024-01712-z. Epub 2024 Sep 3.
In Jordan, no national value set is available for any preference-accompanied health utility measure.
This study aims to develop a value set for EQ-5D-3L based on the preferences of the Jordanian general population.
A representative sample of the Jordanian general population was obtained through quota sampling involving age, gender, and region. Participants aged above 18 years were interviewed via videoconferencing using the EuroQol Valuation Technology 2.1 protocol. Participants completed ten composite time trade-offs (cTTO) and ten discrete choice experiments (DCE) tasks. cTTO and DCE data were analyzed using linear and logistic regression models, respectively, and hybrid models were applied to the combined DCE and cTTO data.
A total of 301 participants with complete data were included in the analysis. The sample was representative of the general population regarding region, age, and gender. All model types applied, that is, random intercept model, random intercept Tobit, linear model with correction for heteroskedasticity, Tobit with correction for heteroskedasticity, and all hybrid models, were statistically significant. They showed logical consistency in terms of higher utility decrements with more severe levels. The hybrid model corrected for heteroskedasticity was selected to construct the Jordanian EQ-5D-3L value set as it showed the best fit and lowest mean absolute error. The predicted value for the most severe health state (33333) was - 0.563. Utility decrements due to mobility had the largest weight, followed by anxiety/depression, while usual activities had the smallest weight.
This study provides the first EQ-5D-3L value set in the Middle East. The Jordanian EQ-5D-3L value set can now be used in health technology assessments for health policy planning by the Jordanian health sector's decision-makers.
在约旦,尚无任何带有偏好的健康效用测量的国家价值集。
本研究旨在根据约旦普通人群的偏好制定EQ-5D-3L价值集。
通过涉及年龄、性别和地区的配额抽样获得约旦普通人群的代表性样本。18岁以上的参与者通过视频会议使用欧洲生活质量评估技术2.1协议进行访谈。参与者完成了十个复合时间权衡(cTTO)和十个离散选择实验(DCE)任务。分别使用线性和逻辑回归模型分析cTTO和DCE数据,并将混合模型应用于合并的DCE和cTTO数据。
分析纳入了301名具有完整数据的参与者。该样本在地区、年龄和性别方面代表了普通人群。所应用的所有模型类型,即随机截距模型、随机截距托比特模型、具有异方差校正的线性模型、具有异方差校正的托比特模型以及所有混合模型,均具有统计学意义。它们在更严重水平下效用下降更高方面显示出逻辑一致性。选择具有异方差校正的混合模型来构建约旦EQ-5D-3L价值集,因为它显示出最佳拟合和最低平均绝对误差。最严重健康状态(33333)的预测值为-0.563。因行动能力受限导致的效用下降权重最大,其次是焦虑/抑郁,而日常活动的权重最小。
本研究提供了中东地区首个EQ-5D-3L价值集。约旦EQ-5D-3L价值集现在可用于约旦卫生部门决策者进行卫生政策规划的卫生技术评估。