el Nahas S M, de Hondt H A, Ramadan A I
Unit of Cell Biology, National Research Centre, Cairo, Egypt.
Environ Mol Mutagen. 1988;11(4):515-22. doi: 10.1002/em.2850110412.
Cytogenetic effects produced in somatic cells by Curacron, a phosphoric acid ester insecticide, were assessed in mice by three criteria: chromosome aberrations, sister chromatid exchange (SCE), and micronucleus induction. Curacron significantly increased the frequency of all three in an apparent dose-dependent manner. Curacron also inhibited the mitotic activity. The increased number of micronuclei is comparable to the increase in chromosome aberrations; the latter were mainly breaks. The frequency of SCE was considerably less than the frequencies of micronuclei and chromosome aberrations.
染色体畸变、姐妹染色单体交换（SCE）和微核诱导。速灭磷以明显的剂量依赖性方式显著增加了所有这三项的频率。速灭磷还抑制有丝分裂活性。微核数量的增加与染色体畸变的增加相当；后者主要是断裂。SCE的频率远低于微核和染色体畸变的频率。
