肝脏X受体与肝脏生理学
Liver X receptors and liver physiology.
作者信息
Russo-Savage Lillian, Schulman Ira G
机构信息
Department of Pharmacology, University of Virginia, School of Medicine, United States of America.
Department of Pharmacology, University of Virginia, School of Medicine, United States of America.
出版信息
Biochim Biophys Acta Mol Basis Dis. 2021 Jun 1;1867(6):166121. doi: 10.1016/j.bbadis.2021.166121. Epub 2021 Mar 11.
Abstract
The liver x receptors LXRα (NR1H3) and LXRβ (NR1H2) are members of the nuclear hormone receptor superfamily of ligand dependent transcription factors that regulate transcription in response to the direct binding of cholesterol derivatives. Studies using genetic knockouts and synthetic ligands have defined the LXRs as important modulators of lipid homeostasis throughout the body. This review focuses on the control of cholesterol and fatty acid metabolism by LXRs in the liver and how modifying LXR activity can influence the pathology of liver diseases.
摘要
肝脏X受体LXRα（NR1H3）和LXRβ（NR1H2）是核激素受体超家族中依赖配体的转录因子成员，它们通过胆固醇衍生物的直接结合来调节转录。使用基因敲除和合成配体的研究已将LXRs定义为全身脂质稳态的重要调节因子。本综述重点关注肝脏中LXRs对胆固醇和脂肪酸代谢的调控，以及改变LXR活性如何影响肝脏疾病的病理过程。
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