参与脂肪肝疾病发病机制的脂质感应核受体。
Lipid sensing nuclear receptors involved in the pathogenesis of fatty liver disease.
作者信息
Schweiger Marion, Arredondo-Lasso Maria Nieves, Friano Marika E, Gil-Lozano Manuel, Herzig Stephan, Uhlenhaut Nina Henriette
机构信息
Metabolic Programming, TUM School of Life Sciences & ZIEL Institute for Food and Health, Gregor-Mendel-Str. 2, 85354, Freising, Germany.
Institute for Diabetes and Endocrinology (IDE), Helmholtz Munich, Ingolstaedter Landstr. 1, 85764, Neuherberg, Germany.
出版信息
FEBS Lett. 2024 Dec;598(23):2854-2855. doi: 10.1002/1873-3468.14818. Epub 2024 Feb 13.
Abstract
Non-alcoholic fatty liver disease (NAFLD) begins with lipid accumulation and progresses toward inflammation and fibrosis. Nuclear receptors (NRs), like the Peroxisome Proliferator-Activated Receptors alpha and gamma (PPARα and PPARy), the Farnesoid X Receptor (FXR), and the Liver X receptor (LXR), regulate genes by heterodimerizing with Retinoid X receptor (RXR). These receptors are emerging targets for pharmaceutical intervention for metabolic diseases.
摘要
非酒精性脂肪性肝病（NAFLD）始于脂质蓄积，并向炎症和纤维化发展。核受体（NRs），如过氧化物酶体增殖物激活受体α和γ（PPARα和PPARγ）、法尼醇X受体（FXR）和肝X受体（LXR），通过与视黄醇X受体（RXR）形成异二聚体来调节基因。这些受体正成为代谢性疾病药物干预的新兴靶点。
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