Institute of Endocrinology, Diabetes, and Metabolism, Max Healthcare, New Delhi, India.
Institute of Endocrinology, Diabetes, and Metabolism, Max Healthcare, New Delhi, India.
Indian Heart J. 2021 Jan-Feb;73(1):74-76. doi: 10.1016/j.ihj.2020.11.005. Epub 2020 Nov 10.
HCQ is a commonly recommended drug for the prophylaxis of COVID-19. One of its rare side-effect includes QTc prolongation.
This was a prospective, cross sectional and observational study conducted on Hydroxychloroquine (HCQ) among Healthcare Workers (HCWs) at Max Super Speciality Hospital, Saket, New Delhi, India. A 3-lead ECG (only limb leads, it does not require chest leads) was performed. The QTc cut offs were pre decided, QTC < 470 ms for males and <480 ms for females was considered within the normal limits and anything above this was regarded as QTc prolongation.
There were 274 HCWs enrolled into the study, including 175 males and 99 females. Majority of the HCWs were young and had a mean age of 32.19 ± 9.29 years. Out of these, 218 were taking HCQ as per the Indian Council of Medical Research (ICMR) guidelines. The median cumulative dose being taken was 1600 mg and the median QTc of these participants was 390 ms in males and 391.5 ms in females. Subsequently, 33 participants were followed-up and found to have a median QTc of 389 ms and a cumulative dose of HCQ as 2000 mg.
In conclusion, ours is a first study in the middle of the pandemic which showed that HCQ prophylaxis in young HCWs without comorbidities did not show any QTc prolongation.
羟氯喹是一种常用于预防 COVID-19 的药物。其罕见的副作用之一包括 QTc 延长。
这是一项在印度新德里萨克特大都会超级专科医院（Max Super Speciality Hospital）对医护人员（HCWs）使用羟氯喹（HCQ）的前瞻性、横断面和观察性研究。进行了 3 导联心电图（仅肢体导联，不需要胸导联）。预先确定了 QTc 截止值，男性 QTc<470ms 和女性 QTc<480ms 被认为在正常范围内，任何高于此值的均被视为 QTc 延长。
共有 274 名 HCWs 参加了这项研究，其中 175 名男性和 99 名女性。大多数 HCWs 年龄较轻，平均年龄为 32.19±9.29 岁。其中 218 人按照印度医学研究理事会（ICMR）的指南服用羟氯喹。中位累积剂量为 1600mg，这些参与者的中位 QTc 男性为 390ms，女性为 391.5ms。随后，对 33 名参与者进行了随访，发现他们的中位 QTc 为 389ms，累积羟氯喹剂量为 2000mg。
总之，这是大流行期间的第一项研究，表明在没有合并症的年轻 HCWs 中使用羟氯喹预防不会导致 QTc 延长。
