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差异表达 circRNAs/lncRNAs 在 Nrf2 敲除小鼠前额叶皮层中的功能预测。

Functional predication of differentially expressed circRNAs/lncRNAs in the prefrontal cortex of Nrf2-knockout mice.

机构信息

Department of Human Anatomy, Institute of Medicine and Health, Hebei Medical University, Shijiazhuang 050017, Hebei, China.

Department of Biochemistry and Molecular Biology, Hebei Medical University, Shijiazhuang 050017, Hebei, China.

出版信息

Aging (Albany NY). 2021 Mar 10;13(6):8797-8816. doi: 10.18632/aging.202688.

DOI:10.18632/aging.202688
PMID:33714958
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8034947/
Abstract

In the central nervous system, nuclear factor erythroid-2-related factor 2 (Nrf2) protects neurons from oxidant injury, thereby ameliorating neurodegeneration. We explored the key circular RNAs (circRNAs) and long non-coding RNAs (lncRNAs) involved in Nrf2-induced neuroprotection. We used microarrays to examine the circRNAs (DEcircRNAs), lncRNAs (DElncRNAs) and mRNAs (DEmRNAs) differentially expressed between Nrf2 (+/+) and Nrf2 (-/-) mice and identified DEcircRNA/DElncRNA-miRNA-DEmRNA interaction networks. In total, 197 DEcircRNAs, 685 DElncRNAs and 356 DEmRNAs were identified in prefrontal cortical tissues from Nrf2 (-/-) mice. The expression patterns of selected DEcircRNAs (except for mmu_circ_0003404) and DElncRNAs in qRT-PCR analyses were generally consistent with the microarray analysis results. Functional annotation of the DEmRNAs in the DEcircRNA/DElncRNA-miRNA-DEmRNA networks indicated that five non-coding RNAs (mmu_circ_0000233, ENSMUST00000204847, NONMMUT024778, NONMMUT132160 and NONMMUT132168) may contribute to Nrf2 activity, with the help of mmu_circ_0015035 and NONMMUT127961. The results also revealed that four non-coding RNAs (cicRNA.20127, mmu_circ_0012936, ENSMUST00000194077 and NONMMUT109267) may influence glutathione metabolism. Additionally, 44 DEcircRNAs and 7 DElncRNAs were found to possess coding potential. These findings provide clues to the molecular pathways through which Nrf2 protects neurons.

摘要

在中枢神经系统中，核因子红细胞 2 相关因子 2 (Nrf2) 可保护神经元免受氧化剂损伤，从而改善神经退行性变。我们探讨了与 Nrf2 诱导的神经保护作用相关的关键环状 RNA (circRNA) 和长链非编码 RNA (lncRNA)。我们使用微阵列检测 Nrf2 (+/+) 和 Nrf2 (-/-) 小鼠之间差异表达的 circRNA (DEcircRNA)、lncRNA (DElncRNA) 和 mRNA (DEmRNA)，并鉴定出 DEcircRNA/DElncRNA-miRNA-DEmRNA 相互作用网络。在 Nrf2 (-/-) 小鼠的前额皮质组织中，共鉴定出 197 个 DEcircRNA、685 个 DElncRNA 和 356 个 DEmRNA。选择的 DEcircRNA (除了 mmu_circ_0003404) 和 DElncRNA 在 qRT-PCR 分析中的表达模式与微阵列分析结果基本一致。DEcircRNA/DElncRNA-miRNA-DEmRNA 网络中 DEmRNA 的功能注释表明，五个非编码 RNA (mmu_circ_0000233、ENSMUST00000204847、NONMMUT024778、NONMMUT132160 和 NONMMUT132168) 可能在 mmu_circ_0015035 和 NONMMUT127961 的帮助下，有助于 Nrf2 活性。结果还表明，四个非编码 RNA (cicRNA.20127、mmu_circ_0012936、ENSMUST00000194077 和 NONMMUT109267) 可能影响谷胱甘肽代谢。此外，还发现 44 个 DEcircRNA 和 7 个 DElncRNA 具有编码潜力。这些发现为 Nrf2 保护神经元的分子途径提供了线索。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/929f/8034947/f0b0ba81455c/aging-13-202688-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/929f/8034947/59d744823912/aging-13-202688-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/929f/8034947/28b09b08120b/aging-13-202688-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/929f/8034947/1c2d285f58fa/aging-13-202688-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/929f/8034947/f78b6898037d/aging-13-202688-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/929f/8034947/18ab9ed50a61/aging-13-202688-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/929f/8034947/f0b0ba81455c/aging-13-202688-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/929f/8034947/59d744823912/aging-13-202688-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/929f/8034947/28b09b08120b/aging-13-202688-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/929f/8034947/1c2d285f58fa/aging-13-202688-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/929f/8034947/f78b6898037d/aging-13-202688-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/929f/8034947/18ab9ed50a61/aging-13-202688-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/929f/8034947/f0b0ba81455c/aging-13-202688-g006.jpg

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