Vallejo-Garcia V E, Barrio-Rodriguez A, Heras-Benito M
Complejo Asistencial de Salamanca, Hospital Universitario de Salamanca, Salamanca (Castilla y León), España.
Servicio de Cardiología, Complejo Asistencial de Salamanca, Hospital Universitario de Salamanca, Salamanca (Castilla y León), España.
Hipertens Riesgo Vasc. 2021 Jul-Sep;38(3):e10-e12. doi: 10.1016/j.hipert.2021.02.004. Epub 2021 Feb 13.
Liquorice is one of the oldest known herbs with medicinal properties and comprises up to 300 active compounds. It has been used for millennia for its digestive, anti-inflammatory and anti-infective properties. However, its possible toxic effects were described only a few years ago and there is growing interest in the side effects associated with chronic consumption. The main active component of liquorice is the prodrug glycyrrhizin and its active metabolite glycyrrhetic acid. It is a rare cause of hypokalaemia due to suppression of the renin-angiotensin-aldosterone axis, causing pseudohyperaldostenonism (PHA). We describe a rare case of secondary acute myocardial infarction in a patient with chronic consumption of liquorice.
甘草是已知最古老的具有药用特性的草药之一，含有多达300种活性化合物。数千年来，它一直因其消化、抗炎和抗感染特性而被使用。然而，其可能的毒性作用直到几年前才被描述，并且人们对长期食用相关的副作用越来越感兴趣。甘草的主要活性成分是前体药物甘草酸及其活性代谢产物甘草次酸。它是由于肾素 - 血管紧张素 - 醛固酮轴受抑制导致低钾血症的罕见原因，从而引起假性醛固酮增多症（PHA）。我们描述了一例长期食用甘草的患者发生继发性急性心肌梗死的罕见病例。
