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Lysobisphosphatidic acid (LBPA) enrichment promotes cholesterol egress via exosomes in Niemann Pick type C1 deficient cells.

作者信息

Ilnytska Olga, Jeziorek Maciej, Lai Kimberly, Altan-Bonnet Nihal, Dobrowolski Radek, Storch Judith

机构信息

Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ 08901, USA; Rutgers Center for Lipid Research, Institute for Food Nutrition and Health, Rutgers University, New Brunswick, NJ 08901, USA.

Department of Biological Sciences, Rutgers University, Newark, NJ 07102, USA.

出版信息

Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Jun;1866(6):158916. doi: 10.1016/j.bbalip.2021.158916. Epub 2021 Mar 12.

DOI:10.1016/j.bbalip.2021.158916
PMID:33716137
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8038758/
Abstract
摘要

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Lysobisphosphatidic acid (LBPA) enrichment promotes cholesterol egress via exosomes in Niemann Pick type C1 deficient cells.溶血双磷脂酸（LBPA）富集通过外泌体促进尼曼-皮克C1型缺陷细胞中的胆固醇流出。
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2
Enrichment of NPC1-deficient cells with the lipid LBPA stimulates autophagy, improves lysosomal function, and reduces cholesterol storage.用脂质 LBPA 富集 NPC1 缺陷细胞可刺激自噬，改善溶酶体功能，并减少胆固醇储存。
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本文引用的文献

1
Niemann Pick C2 protein enables cholesterol transfer from endo-lysosomes to the plasma membrane for efflux by shedding of extracellular vesicles.尼曼-匹克 C2 蛋白可将胆固醇从内溶酶体转移到质膜，通过胞外小泡的脱落实现外排。
Chem Phys Lipids. 2021 Mar;235:105047. doi: 10.1016/j.chemphyslip.2020.105047. Epub 2021 Jan 7.
2
Bis(monoacylglycero)phosphate, a new lipid signature of endosome-derived extracellular vesicles.双（单酰基甘油）磷酸酯，内体衍生细胞外囊泡的新型脂质标志物。
Biochimie. 2020 Nov;178:26-38. doi: 10.1016/j.biochi.2020.07.005. Epub 2020 Jul 10.
3
Exosome Production Is Key to Neuronal Endosomal Pathway Integrity in Neurodegenerative Diseases.外泌体产生是神经退行性疾病中神经元内体途径完整性的关键。
Front Neurosci. 2019 Dec 12;13:1347. doi: 10.3389/fnins.2019.01347. eCollection 2019.
4
Intracellular cholesterol trafficking is dependent upon NPC2 interaction with lysobisphosphatidic acid.细胞内胆固醇转运依赖于 NPC2 与溶血磷脂酸的相互作用。
Elife. 2019 Oct 3;8:e50832. doi: 10.7554/eLife.50832.
5
NPC intracellular cholesterol transporter 1 (NPC1)-mediated cholesterol export from lysosomes.NPC 细胞内胆固醇转运蛋白 1（NPC1）介导的溶酶体胆固醇输出。
J Biol Chem. 2019 Feb 1;294(5):1706-1709. doi: 10.1074/jbc.TM118.004165.
6
Cyclodextrin triggers MCOLN1-dependent endo-lysosome secretion in Niemann-Pick type C cells.环糊精触发尼曼-匹克 C 型细胞中 MCOLN1 依赖性内溶酶体分泌。
J Lipid Res. 2019 Apr;60(4):832-843. doi: 10.1194/jlr.M089979. Epub 2019 Feb 1.
7
Miglustat in Niemann-Pick disease type C patients: a review.尼曼-匹克病 C 型患者的米格列醇治疗：综述。
Orphanet J Rare Dis. 2018 Aug 15;13(1):140. doi: 10.1186/s13023-018-0844-0.
8
Cholesterol and the journey of extracellular vesicles.胆固醇与细胞外囊泡的旅程。
J Lipid Res. 2018 Dec;59(12):2255-2261. doi: 10.1194/jlr.R084210. Epub 2018 Apr 20.
9
Acyl chain asymmetry and polyunsaturation of brain phospholipids facilitate membrane vesiculation without leakage.脑磷脂酰基链的不对称性和多不饱和性有助于膜泡形成而不发生渗漏。
Elife. 2018 Mar 15;7:e34394. doi: 10.7554/eLife.34394.
10
Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures.神经元溶酶体功能障碍会释放携带淀粉样前体蛋白（APP）C末端片段和独特脂质特征的外泌体。
Nat Commun. 2018 Jan 18;9(1):291. doi: 10.1038/s41467-017-02533-w.