Hobbs Kelsey A, Mann Frank D, Cole Steven W, Krueger Robert F
University of Minnesota, Twin Cities Department of Psychology 75 E River Rd Minneapolis, MN 55455, United states.
University of California, Los Angeles Department of Psychiatry & Biobehavioral Sciences and Medicine 11-934 Factor Building Los Angeles, CA 90095, United States.
Pers Individ Dif. 2021 Feb 1;169. doi: 10.1016/j.paid.2020.109908. Epub 2020 Feb 28.
A previous study found that Extraversion and Conscientiousness were associated with increased and decreased expression of a pre-specified set of pro-inflammatory indicator genes. The present study aimed to replicate these findings in a sample of adults from the Refresher Cohort of the Study of Midlife in the United States (MIDUS). Analysis of gene expression composite scores and generalized linear models that took into account the heterogeneity and non-independence of RNA expression across different genes found no significant associations between the pro-inflammatory indicator gene set and the Big Five domains of personality. In addition, there was no significant association between a pre-specified antiviral indicator gene set and the Big Five domains. These findings suggest that relations between Big Five personality and expression of these two immune response indicator gene sets do not consistently appear across samples and may be context-dependent in ways that remain to be elucidated.
先前的一项研究发现，外向性和尽责性分别与一组预先指定的促炎指标基因的表达增加和减少相关。本研究旨在在美国中年发展研究（MIDUS）复习队列的成年人样本中重复这些发现。对基因表达综合评分以及考虑了不同基因间RNA表达的异质性和非独立性的广义线性模型进行分析后发现，促炎指标基因集与人格五因素之间没有显著关联。此外，预先指定的抗病毒指标基因集与人格五因素之间也没有显著关联。这些发现表明，人格五因素与这两组免疫反应指标基因表达之间的关系并非在所有样本中都一致出现，可能在某些方面依赖于具体情境，而这些情境仍有待阐明。
