Cancer Center, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Hospital of the University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
J Cell Mol Med. 2018 Jan;22(1):4-15. doi: 10.1111/jcmm.13293. Epub 2017 Aug 7.
Bladder cancer (BC) is one of the most common cancers worldwide with a high progression rate and poor prognosis. The Hippo signalling pathway is a conserved pathway that plays a crucial role in cellular proliferation, differentiation and apoptosis. Furthermore, dysregulation and/or malfunction of the Hippo pathway is common in various human tumours, including BC. In this review, an overview of the Hippo pathway in BC and other cancers is presented. We focus on recent data regarding the Hippo pathway, its network and the regulation of the downstream co-effectors YAP1/TAZ. The core components of the Hippo pathway, which induce BC stemness acquisition, metastasis and chemoresistance, will be emphasized. Additional research on the Hippo pathway will advance our understanding of the mechanism of BC as well as the development and progression of other cancers and may be exploited therapeutically.
膀胱癌（BC）是全球最常见的癌症之一，具有较高的进展率和较差的预后。Hippo 信号通路是一条保守的通路，在细胞增殖、分化和凋亡中发挥着关键作用。此外，Hippo 通路的失调和/或功能障碍在包括 BC 在内的各种人类肿瘤中很常见。在这篇综述中，我们介绍了 Hippo 通路在 BC 和其他癌症中的作用。我们重点介绍了最近关于 Hippo 通路、其网络以及下游共效应物 YAP1/TAZ 调节的相关数据。Hippo 通路的核心成分可诱导 BC 干性获得、转移和化疗耐药性，我们将对此进行重点强调。对 Hippo 通路的进一步研究将有助于我们理解 BC 以及其他癌症的发生和发展的机制，并可能为治疗提供依据。
