The CrossTalk Group, Institute of Oral Biology, University of Oslo, Oslo, Norway.
Department of Periodontology, Tufts University School of Dental Medicine, Boston, MA, United States.
Front Immunol. 2021 Feb 24;12:632238. doi: 10.3389/fimmu.2021.632238. eCollection 2021.
The recent outbreak of SARS-CoV2 has emerged as one of the biggest pandemics of our century, with outrageous health, social and economic consequences globally. Macrophages may lay in the center of COVID-19 pathogenesis and lethality and treatment of the macrophage-induced cytokine storm has emerged as essential. Specialized pro-resolving mediators (SPMs) hold strong therapeutic potentials in the management of COVID-19 as they can regulate macrophage infiltration and cytokine production but also promote a pro-resolving macrophage phenotype. In this review, we discuss the homeostatic functions of SPMs acting directly on macrophages on various levels, towards the resolution of inflammation. Moreover, we address the molecular events that link the lipid mediators with COVID-19 severity and discuss the clinical potentials of SPMs in COVID-19 immunotherapeutics.
最近爆发的 SARS-CoV2 已成为本世纪最大的流行病之一，在全球范围内造成了严重的健康、社会和经济后果。巨噬细胞可能处于 COVID-19 发病机制和致死率的中心，而治疗巨噬细胞诱导的细胞因子风暴已成为关键。专门的促解决介质（SPM）在 COVID-19 的管理中具有强大的治疗潜力，因为它们可以调节巨噬细胞浸润和细胞因子产生，同时促进促解决的巨噬细胞表型。在这篇综述中，我们讨论了 SPM 直接作用于各种水平的巨噬细胞的稳态功能，以实现炎症的解决。此外，我们还探讨了将脂质介质与 COVID-19 严重程度联系起来的分子事件，并讨论了 SPM 在 COVID-19 免疫治疗中的临床潜力。
