Association between airflow limitation and prognosis in patients with chronic pulmonary aspergillosis.

BACKGROUND

Previous studies have shown that reduced levels of lung function, characterized by forced expiratory volume in 1 second (FEV), are associated with higher respiratory events and mortality in general population and some chronic lung diseases. Chronic pulmonary aspergillosis (CPA) is a destructive, fatal lung disease caused by infection in non-immunocompromised patients with suboptimal pulmonary function. However, there is limited information on the status and features of CPA according to FEV.

METHODS

We performed a retrospective observational study to investigate the FEV and airflow limitation in patients with CPA between March 2017 and February 2019 at a tertiary hospital in South Korea.

RESULTS

Of the 144 CPA patients, 104 underwent spirometry, demonstrating median forced vital capacity (FVC) and FEV of 2.35 L (68%) and 1.43 L (62%), respectively. Among them, 56 patients had airflow limitation on PFT, with median FVC, and FEV of 2.47 L (73%) and 1.11 L (47%), respectively. Low body mass index (BMI) (20.1 22.1 kg/m; P=0.011), breathlessness (60% 20%; P=0.002), and bilateral pulmonary lesions (33.3% 4%; P=0.006) were more common in patients with moderate to very severe airflow limitation than in those with normal to mild airflow limitation.

CONCLUSIONS

Moderate to very severe airflow limitation was observed in 43.3% of patients with CPA. Additionally, low BMI, breathlessness, and bilateral pulmonary lesions contributing to poor prognosis were more common in patients with moderate to very severe airflow limitation than in those with normal to mild airflow limitation. Our findings suggest that airflow limitation can be associated with the prognosis of CPA. Further investigations are needed to demonstrate the clinical significance of this association.