Flores-Genger H, Husslein P, Knogler W, Metka M, Wagenbichler P, Scholz P, Schnedl W
First Department of Obstetrics and Gynecology, University of Vienna, Austria.
Gynecol Obstet Invest. 1988;25(2):96-8. doi: 10.1159/000293753.
100 patients were examined to evaluate the risk of abortion of chorionic villus sampling. In the 8th-10th week of pregnancy a catheter with a mandrin was introduced into the chorion frondosum under ultrasound guidance. The mandrin was then removed and trophoblast tissue obtained by aspiration. The patients agreed to postpone elective termination of pregnancy for 2 weeks. Another ultrasound was performed before suction curettage. With increasing experience, the abortion rate dropped to 4%, whereas the rate of successful biopsies and analyses rose to more than 90%. Based on these results, chorionic villi sampling was made available at the 1st Department of Obstetrics and Gynecology, University of Vienna, as an alternative method to amniocentesis. Out of 38 biopsies, 25 karyotypes were normal, two biopsies revealed pathological results (trisomy 21, 22), 11 samples showed no results (insufficient tissue or no mitoses). One patient had a spontaneous abortion (trisomy 22) and one an abortion due to infection. Chorionic villus sampling could replace amniocentesis because chromosomal anomalies may be detected already in the 1st trimester of pregnancy.
对100例患者进行了检查，以评估绒毛取样的流产风险。在妊娠第8至10周时，在超声引导下将带有芯杆的导管插入叶状绒毛膜。然后取出芯杆，通过抽吸获取滋养层组织。患者同意将选择性终止妊娠推迟2周。在刮宫术前进行了另一次超声检查。随着经验的增加，流产率降至4%，而成功活检和分析的比例升至90%以上。基于这些结果，维也纳大学第一妇产科将绒毛取样作为羊膜穿刺术的替代方法。在38例活检中，25例核型正常，2例活检显示病理结果（21、22三体），11例样本无结果（组织不足或无有丝分裂）。1例患者自然流产（22三体），1例因感染流产。绒毛取样可以替代羊膜穿刺术，因为在妊娠早期就可以检测到染色体异常。
