Petrou Petros, Angelidis Constantine D, Andreanos Konstantinos, Kanakis Menelaos, Kandarakis Stylianos, Karamaounas Aristotelis, Papakonstantinou Evangelia, Mamas Nikolaos, Droutsas Konstantinos, Georgalas Ilias
Ophthalmology, "G. Gennimatas" General Hospital of Athens, Athens, GRC.
Ophthalmology, "G. Gennimatas" General Hospital of Athens, National and Kapodistrian University of Athens School of Medicine, Athens, GRC.
Cureus. 2021 Mar 7;13(3):e13757. doi: 10.7759/cureus.13757.
To investigate the effect of pars plana vitrectomy on foveal circulation, and in particular the foveal avascular zone (FAZ), using optical coherence tomography angiography (OCTA).
This was a prospective, non-randomized, comparative case series of patients that underwent vitrectomy. Twenty-six eyes of 26 patients that underwent vitrectomy were studied postoperatively by OCTA. Our patients underwent 23 or 25G pars plana vitrectomy (PPV) for any posterior segment pathology. Three-dimensional OCTAs (DRI Triton Swept Source OCT; Topcon) of the capillary plexus were obtained three months post-operatively. The FAZ measurements of the fellow eyes were used as controls.
Change in FAZ area between vitrectomized eyes and controls.
From a total of 26 patients, 17 underwent vitrectomy due to retinal detachment (RD). Almost all patients demonstrated a statistically significant reduction in FAZ size based on the OCTA measurements. Τhe mean difference in FAZ size for the superficial capillary plexus (SCP) was -93.77 ± 71.73 μm and for the deep capillary plexus (DCP) -88.87 ± 75.41 μm, both statistically significant (p=0.000), while the amount of reduction in μm was the same for both SCP and DCP.
The foveal avascular zone seems to be reduced following vitrectomy as shown by optical coherence tomography angiography. It is postulated that this may be the result of changes in the physiology of the vitrectomized eye, and that this change should be attributed to the removal of the vitreous itself rather than other structures such as the internal limiting membrane.
使用光学相干断层扫描血管造影（OCTA）研究玻璃体切除术对黄斑循环，尤其是黄斑无血管区（FAZ）的影响。
这是一个对接受玻璃体切除术患者的前瞻性、非随机、对比病例系列研究。对26例接受玻璃体切除术患者的26只眼进行了术后OCTA研究。我们的患者因任何后段病变接受了23G或25G的玻璃体切除术（PPV）。术后三个月获得了毛细血管丛的三维OCTA（DRI Triton扫频源OCT；拓普康）。对侧眼的FAZ测量值用作对照。
玻璃体切除眼与对照眼之间FAZ面积的变化。
在总共26例患者中，17例因视网膜脱离（RD）接受了玻璃体切除术。几乎所有患者根据OCTA测量显示FAZ大小有统计学意义的减小。浅表毛细血管丛（SCP）的FAZ大小平均差异为-93.77±71.73μm，深部毛细血管丛（DCP）为-88.87±75.41μm，两者均具有统计学意义（p=0.000），而SCP和DCP在μm的减小量相同。
光学相干断层扫描血管造影显示，玻璃体切除术后黄斑无血管区似乎减小。据推测，这可能是玻璃体切除眼生理变化的结果，并且这种变化应归因于玻璃体本身的切除，而不是其他结构，如内界膜。
