Gong Di, Zou Xuan, Zhang Xiao, Yu Weihong, Qu Yi, Dong Fangtian
Ophthalmic Surg Lasers Imaging Retina. 2016 Feb;47(2):142-8. doi: 10.3928/23258160-20160126-07.
To investigate the influence of age and central foveal thickness (CFT) on the foveal avascular zone (FAZ) size in healthy people using optical coherence tomography angiography (OCTA).
A cross-section study. One hundred thirty-two healthy subjects (224 eyes) were included. All participants underwent examination with OCTA. CFT and FAZ size, including vertical radius (VR), horizontal radius (HR), and area, were measured.
Linear regression analysis showed a positive correlation between age and FAZ size. The HR, VR, and area had an increase of 0.001 mm (P = .002), 0.001 mm (P = .001), and 0.001 mm(2) (P = .000) each year, respectively. There was a negative correlation between CFT and FAZ size. When the CFT increased per 1 µm, the HR, VR, and area decreased by 0.002 mm (P = .000), 0.001 mm (P = .000), and 0.003 mm(2) (P = .000), respectively.
FAZ size increases with age and decreases with CFT. OCTA is a novel method to study the FAZ in healthy people.
使用光学相干断层扫描血管造影（OCTA）研究年龄和中心凹厚度（CFT）对健康人黄斑无血管区（FAZ）大小的影响。
一项横断面研究。纳入132名健康受试者（224只眼）。所有参与者均接受OCTA检查。测量CFT和FAZ大小，包括垂直半径（VR）、水平半径（HR）和面积。
线性回归分析显示年龄与FAZ大小呈正相关。HR、VR和面积每年分别增加0.001 mm（P = 0.002）、0.001 mm（P = 0.001）和0.001 mm²（P = 0.000）。CFT与FAZ大小呈负相关。当CFT每增加1 µm时，HR、VR和面积分别减少0.002 mm（P = 0.000）、0.001 mm（P = 0.000）和0.003 mm²（P = 0.000）。
FAZ大小随年龄增加而增大，随CFT减小。OCTA是研究健康人FAZ的一种新方法。
