Zang Yan, Qi Feng, Cheng Yifei, Xia Tian, Xiao Rongrong, Li Xiao, Yang Ningli
Department of Bariatric and Metabolic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Department of Urologic Surgery, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China.
Transl Androl Urol. 2021 Feb;10(2):741-753. doi: 10.21037/tau-20-897.
To shed light on the survival outcomes of prostate cancer (PCa) patients diagnosed after a prior cancer and identify prognostic factors for overall survival (OS) and cancer-specific survival (CSS) in PCa patients.
In the primary group, a total of 1,778 PCa patients with a prior cancer were identified in the Surveillance, Epidemiology, and End Results (SEER) database from 2005 to 2015, retrospectively. Baseline characteristics and causes of death (COD) of these patients were collected and compared. In the second group, a total of 10,296 PCa patients [5,148 patients with PCa as the only malignancy and 5,148 patients with PCa as their second primary malignancy (SPM)] diagnosed between 2010 and 2011 were extracted to investigate the impact of prior cancers on survival outcomes.
In PCa patients with a prior cancer, the most common type of prior cancer was from gastrointestinal system (29.92%), followed by urinary system (21.37%). Patients were more likely to die of the prior caner, and those with prior cancer from respiratory system had the worst survival outcomes. Moreover, the overall ratios in patients with stage (PCa) I-II and III-IV diseases were 0.21 and 1.65, indicating that patients with higher stage diseases were more likely to die of PCa. In the second group, patients with PCa as the SPM had worse OS than those with PCa as the first primary cancer. Lastly, prognostic factors for OS and CSS in PCa patients were explored.
PCa remains to be an important COD for patients with a prior malignancy, especially for those with high-stage diseases. PCa patients with a prior cancer had worse survival outcomes than those without.
为了阐明先前患癌后被诊断出前列腺癌（PCa）患者的生存结果，并确定PCa患者总生存（OS）和癌症特异性生存（CSS）的预后因素。
在第一组中，回顾性地在监测、流行病学和最终结果（SEER）数据库中确定了2005年至2015年期间总共1778例先前患癌的PCa患者。收集并比较了这些患者的基线特征和死亡原因（COD）。在第二组中，提取了2010年至2011年期间诊断的总共10296例PCa患者[5148例PCa为唯一恶性肿瘤的患者和5148例PCa为第二原发性恶性肿瘤（SPM）的患者]，以研究先前癌症对生存结果的影响。
在先前患癌的PCa患者中，最常见的先前癌症类型来自胃肠道系统（29.92%），其次是泌尿系统（21.37%）。患者更有可能死于先前的癌症，先前患有呼吸系统癌症的患者生存结果最差。此外，I-II期和III-IV期疾病患者的总体比率分别为0.21和1.65，这表明疾病分期较高的患者更有可能死于PCa。在第二组中，PCa作为SPM的患者的OS比PCa作为第一原发性癌症的患者更差。最后，探索了PCa患者OS和CSS的预后因素。
对于先前患有恶性肿瘤的患者，PCa仍然是一个重要的COD死因，特别是对于那些患有晚期疾病的患者。先前患癌的PCa患者的生存结果比未患癌患者更差。
