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莪术二酮通过靶向吲哚胺2,3-双加氧酶1对人子宫平滑肌肉瘤发挥抗增殖作用。

Curdione Induces Antiproliferation Effect on Human Uterine Leiomyosarcoma Targeting IDO1.

作者信息

Wei Chao, Li Donghua, Liu Yu, Wang Wenna, Qiu Tiantian

机构信息

School of Traditional Chinese Medicine, Capital Medical University, Beijing, China.

出版信息

Front Oncol. 2021 Feb 26;11:637024. doi: 10.3389/fonc.2021.637024. eCollection 2021.

DOI:10.3389/fonc.2021.637024
PMID:33718227
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7953905/
Abstract

OBJECTIVES

Curdione is one of the active ingredients of a traditional Chinese herbal medicine- and established anti-tumor effects. Uterine leiomyosarcoma (uLMS) is a rare gynecological malignancy, with no standard therapeutic regimen at present. The aim of this study was to explore the potential anti-tumor impact of curdione in uLMS and elucidate the underlying mechanisms.

METHODS

functional assays were performed in the SK-UT-1 and SK-LMS-1 cell lines. The model of uLMS was established by subcutaneously injecting SK-UT-1 cells, and the tumor-bearing mice were intraperitoneally injected with curdione. Tumor weight and volume were measured at specific time points. The biosafety was evaluated by monitoring changes of body weight and the histopathology in the liver and kidney. The expression levels of relevant proteins were analyzed by western blotting and immunohistochemistry.

RESULTS

Curdione decreased the viability and proliferation of uLMS cells in a concentration and time-dependent manner. In addition, the curdione-treated cells exhibited significantly higher rates of apoptosis and autophagic death. Curdione also decreased the tumor weight and volume in the SK-UT-1 xenograft model compared to the untreated control without affecting the body bodyweight or pathological injury of liver and kidney tissues. At the molecular level, the anti-tumor effects of curdione were mediated by indoleamine-2, 3-dioxygenase-1 (IDO1).

CONCLUSION

Curdione exhibited an anti-uLMS effect and ; the underlying mechanism involved in IDO1 mediate apoptosis, autophagy, and G2/M phase arrest.

摘要

目的

莪术二酮是一种传统中药的活性成分，具有明确的抗肿瘤作用。子宫平滑肌肉瘤（uLMS）是一种罕见的妇科恶性肿瘤，目前尚无标准治疗方案。本研究旨在探讨莪术二酮对uLMS的潜在抗肿瘤作用，并阐明其潜在机制。

方法

在SK-UT-1和SK-LMS-1细胞系中进行功能实验。通过皮下注射SK-UT-1细胞建立uLMS模型，对荷瘤小鼠腹腔注射莪术二酮。在特定时间点测量肿瘤重量和体积。通过监测体重变化以及肝脏和肾脏的组织病理学来评估生物安全性。通过蛋白质印迹法和免疫组织化学分析相关蛋白的表达水平。

结果

莪术二酮以浓度和时间依赖性方式降低uLMS细胞的活力和增殖。此外，经莪术二酮处理的细胞表现出显著更高的凋亡率和自噬死亡率。与未处理的对照组相比，莪术二酮在SK-UT-1异种移植模型中也降低了肿瘤重量和体积，且不影响体重或肝肾组织的病理损伤。在分子水平上，莪术二酮的抗肿瘤作用由吲哚胺-2,3-双加氧酶-1（IDO1）介导。

结论

莪术二酮表现出抗uLMS作用，其潜在机制涉及IDO1介导的凋亡、自噬和G2/M期阻滞。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b32e/7953905/a9954ff7f281/fonc-11-637024-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b32e/7953905/1b0ff908f627/fonc-11-637024-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b32e/7953905/5d486bb081f8/fonc-11-637024-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b32e/7953905/05c43a59572a/fonc-11-637024-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b32e/7953905/7928f90218e5/fonc-11-637024-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b32e/7953905/19a66e4cbe35/fonc-11-637024-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b32e/7953905/5055183c1eb8/fonc-11-637024-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b32e/7953905/a9954ff7f281/fonc-11-637024-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b32e/7953905/1b0ff908f627/fonc-11-637024-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b32e/7953905/5d486bb081f8/fonc-11-637024-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b32e/7953905/1f98914220de/fonc-11-637024-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b32e/7953905/876985440c4b/fonc-11-637024-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b32e/7953905/05c43a59572a/fonc-11-637024-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b32e/7953905/7928f90218e5/fonc-11-637024-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b32e/7953905/19a66e4cbe35/fonc-11-637024-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b32e/7953905/5055183c1eb8/fonc-11-637024-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b32e/7953905/a9954ff7f281/fonc-11-637024-g009.jpg

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本文引用的文献

1
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Semin Cancer Biol. 2022 May;80:218-236. doi: 10.1016/j.semcancer.2020.05.015. Epub 2020 Jun 2.
2
Mechanism and potential predictive biomarkers of immune checkpoint inhibitors in NSCLC.非小细胞肺癌免疫检查点抑制剂的作用机制及潜在预测生物标志物。
Biomed Pharmacother. 2020 Jul;127:109996. doi: 10.1016/j.biopha.2020.109996. Epub 2020 May 6.
3
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3 Biotech. 2025 Jun;15(6):153. doi: 10.1007/s13205-025-04318-1. Epub 2025 May 6.
4
Curdione combined with borneol treats bacterial mixed HPV infection by regulating the crosstalk among immune cells.莪术二酮联合冰片通过调节免疫细胞间的相互作用治疗细菌性混合性人乳头瘤病毒感染。
Front Immunol. 2025 Jan 22;16:1503355. doi: 10.3389/fimmu.2025.1503355. eCollection 2025.
5
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Biomolecules. 2024 Mar 23;14(4):387. doi: 10.3390/biom14040387.
6
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Chin Med. 2023 Sep 21;18(1):122. doi: 10.1186/s13020-023-00820-x.
7
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Antibiotics (Basel). 2022 Nov 3;11(11):1547. doi: 10.3390/antibiotics11111547.
8
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9
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5
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6
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7
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Phytomedicine. 2019 Aug;61:152859. doi: 10.1016/j.phymed.2019.152859. Epub 2019 Feb 4.
8
A delicate balance - The BCL-2 family and its role in apoptosis, oncogenesis, and cancer therapeutics.微妙的平衡 - BCL-2 家族及其在细胞凋亡、肿瘤发生和癌症治疗中的作用。
Biochem Pharmacol. 2019 Apr;162:250-261. doi: 10.1016/j.bcp.2019.01.015. Epub 2019 Jan 19.
9
Association of astragaloside IV-inhibited autophagy and mineralization in vascular smooth muscle cells with lncRNA H19 and DUSP5-mediated ERK signaling.黄芪甲苷抑制血管平滑肌细胞自噬和矿化与长链非编码 RNA H19 和 DUSP5 介导的 ERK 信号的关系。
Toxicol Appl Pharmacol. 2019 Feb 1;364:45-54. doi: 10.1016/j.taap.2018.12.002. Epub 2018 Dec 5.
10
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Pharmacol Ther. 2019 Apr;196:105-116. doi: 10.1016/j.pharmthera.2018.12.004. Epub 2018 Dec 4.