Rahman Shaikh Shahinur, Salauddin Hussain Mohammad, Rahman Mahfuzur, Muhsin Mir Mohammad, Rouf Shakh Ma
Department of Applied Nutrition and Food Technology, Islamic University, Kushtia, Bangladesh.
Bangladesh Agricultural Research Council (BARC), Farmgate, Dhaka, Bangladesh.
Biochem Biophys Rep. 2021 Jan 20;25:100917. doi: 10.1016/j.bbrep.2021.100917. eCollection 2021 Mar.
Diabetic patients usually avoid germinated endosperm of sugar palm (GESP) and elephant foot yam tuber (EFYT), fearing that these may further deteriorate existing hyperglycemia. In the present study, this suspicion was investigated by analyzing the nutrients and following the animal experiments by supplementary feeding powder of GESP, EFYT, and their mixture in addition to the regular diet for the six consecutive weeks. Next three weeks, the powder was withdrawn, and fasting blood glucose (FBG) levels were recorded from the beginning. The results clearly showed that these foodstuffs significantly ( < 0.001) reduced FBG levels of alloxan-induced diabetic rats. The mixture of GESP & EFYT showed the maximum antidiabetic effects followed by GESP and EFYT, respectively. GESP, as well as the mixture, returned the FBG levels of diabetic rats within the normal range by the end of the 6th week, even after withdrawing the powder, but not by the EFYT. These results suggested that the foodstuffs may restore the damaged pancreatic β-cell functions by the end of the 6th week. Nutrient contents like fiber, zinc, as well as antidiabetogenic phytochemicals present in these foodstuffs, could perform these functions.
糖尿病患者通常会避开糖棕发芽胚乳(GESP)和象腿山药块茎(EFYT),担心这些食物可能会使现有的高血糖状况进一步恶化。在本研究中,通过分析这些食物的营养成分,并在连续六周的常规饮食基础上,额外补充GESP、EFYT及其混合物的粉末进行动物实验,来探究这一疑虑。接下来的三周,停止补充粉末,并从一开始就记录空腹血糖(FBG)水平。结果清楚地表明,这些食物显著(<0.001)降低了四氧嘧啶诱导的糖尿病大鼠的FBG水平。GESP和EFYT的混合物显示出最大的抗糖尿病作用,其次分别是GESP和EFYT。到第6周结束时,即使停止补充粉末,GESP以及混合物也能使糖尿病大鼠的FBG水平恢复到正常范围,但EFYT则不能。这些结果表明,到第6周结束时,这些食物可能会恢复受损的胰腺β细胞功能。这些食物中含有的纤维、锌等营养成分以及抗糖尿病的植物化学物质可能发挥了这些作用。