Department of Ophthalmology, Mustafa Kemal University Tayfur Ata Sökmen Faculty of Medicine, Hatay, Turkey.
Department of Rheumatology, Mustafa Kemal University Tayfur Ata Sökmen Faculty of Medicine, Turkey.
Clin Exp Optom. 2022 Jan;105(1):61-64. doi: 10.1080/08164622.2021.1896335. Epub 2021 Mar 15.
The relationship between the cornea and systemic autoimmune diseases has been demonstrated in prior studies. Corneal Visualisation Scheimpflug Technology (Corvis ST) provides a specific and detailed assessment of corneal biomechanical features, such as stiffness and elasticity.
This study aims to evaluate corneal biomechanical changes in patients with systemic autoimmune diseases using Corvis ST.
This prospective study included 36 patients with ankylosing spondylitis (AS), 38 patients with rheumatoid arthritis (RA), and 36 age- and sex-matched healthy subjects. After ophthalmologic examinations Pentacam HR and Corvis ST was performed on all eyes. The mean keratometric and pachymetric data, corneal biomechanical parameters, biomechanical intraocular pressure (bIOP) were analysed.
There was no statistically significant differences among the groups regarding age, gender, refraction, visual acuity, IOP, pachymetry and keratometry. Compared to healthy controls, the mean velocity values of applanation 1 (A1V) and 2 (A2V), deformation amplitude (DA), and corvis biomechanical index (CBI) were statistically significantly higher and stiffness parameter at first applanation (SPA1) was statistically significantly lower in AS and RA patients (all p < 0.05). In both AS and RA groups, disease duration was found to be negatively correlated with SPA1 (p = 0.043, 0.027, respectively) and positively correlated with CBI (p = 0.022, 0.020, respectively).
AS and RA patients have a decreased corneal stiffness compared to healthy subjects. Disease duration seems to be correlated with these changes.
先前的研究已经证明了角膜与系统性自身免疫性疾病之间的关系。角膜可视化Scheimpflug 技术（Corvis ST）提供了对角膜生物力学特征（如硬度和弹性）的具体和详细评估。
本研究旨在使用 Corvis ST 评估系统性自身免疫性疾病患者的角膜生物力学变化。
这项前瞻性研究纳入了 36 例强直性脊柱炎（AS）患者、38 例类风湿关节炎（RA）患者和 36 名年龄和性别匹配的健康对照者。所有患者均进行眼科检查 Pentacam HR 和 Corvis ST。分析平均角膜曲率和厚度数据、角膜生物力学参数、生物力学眼压（bIOP）。
三组间年龄、性别、屈光不正、视力、眼压、角膜厚度和角膜曲率无统计学差异。与健康对照组相比，AS 和 RA 患者的角膜第一压平速度（A1V）和第二压平速度（A2V）、变形幅度（DA）和角膜生物力学指数（CBI）的平均值显著较高，而首次压平的刚性参数（SPA1）显著较低（均 p<0.05）。在 AS 和 RA 组中，疾病持续时间与 SPA1 呈负相关（p=0.043、0.027），与 CBI 呈正相关（p=0.022、0.020）。
与健康对照组相比，AS 和 RA 患者的角膜硬度降低。疾病持续时间似乎与这些变化相关。
