Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Curr Neurovasc Res. 2021;18(1):4-11. doi: 10.2174/1567202618666210311122419.
Coronavirus disease 2019 (COVID-19) has spread worldwide and poses a great threat to global health. COVID-19 has also an unneglected effect on migraine patients. Migraine attack frequency is one of the migraine characteristics, and its impact during COVID-19 needs further research. We aimed to evaluate whether migraine attack frequency during the COVID-19 pandemic differed from pre-COVID-19 attack frequency and explore possible influencing factors during the pandemic.
This prospective cohort study enrolled 187 migraine patients from the Department of Neurology of West China Hospital from October 2019 to December 2019. After the inclusion and exclusion criteria, a total of 157 patients were included. We collected demographic data, clinical characteristics, and epidemiological contact information and followed up on March 2020. Then, paired-samples T-tests, logistic regression and interaction tests were used to analyze the data.
We found that the migraine attack frequency was 2.47 ± 1.12 before and 3.54 ± 1.79 during COVID-19 (P<0.0001). Then, we divided patients into two groups based on the difference in migraine attack frequency between the COVID-19 and pre-COVID-19 periods and employed logistic regression analysis. In the logistic regression analysis, divorced status (OR = 6.53, P = 0.0453), good sleep pre-COVID-19 and poor sleep during COVID-19 (OR = 3.11, P = 0.0432) had independent effects on migraine attack frequency during the COVID-19 pandemic. We found no interaction in poor sleep during COVID-19 between various subgroups.
We found that migraineurs' headache attacks were more frequent during COVID-19 than pre-COVID-19 and that increased migraine attack frequency was independently related to divorced status and poor sleep during COVID-19.
2019 年冠状病毒病（COVID-19）已在全球范围内传播，对全球健康构成了巨大威胁。COVID-19 也给偏头痛患者带来了不容忽视的影响。偏头痛发作频率是偏头痛特征之一，其在 COVID-19 期间的影响需要进一步研究。我们旨在评估 COVID-19 大流行期间偏头痛发作频率是否与 COVID-19 前的发作频率不同，并探讨大流行期间可能的影响因素。
本前瞻性队列研究纳入了 2019 年 10 月至 12 月期间来自华西医院神经内科的 187 例偏头痛患者。纳入和排除标准后，共纳入 157 例患者。我们收集了人口统计学数据、临床特征和流行病学接触信息，并于 2020 年 3 月进行了随访。然后，采用配对样本 T 检验、逻辑回归和交互检验进行数据分析。
我们发现偏头痛发作频率在 COVID-19 前为 2.47 ± 1.12，在 COVID-19 期间为 3.54 ± 1.79（P<0.0001）。然后，我们根据 COVID-19 前后偏头痛发作频率的差异将患者分为两组，并进行逻辑回归分析。在逻辑回归分析中，离婚状态（OR=6.53，P=0.0453）、COVID-19 前睡眠良好和 COVID-19 期间睡眠不佳（OR=3.11，P=0.0432）对 COVID-19 期间偏头痛发作频率有独立影响。我们发现 COVID-19 期间睡眠不佳在各亚组之间没有交互作用。
我们发现偏头痛患者在 COVID-19 期间头痛发作比 COVID-19 前更频繁，偏头痛发作频率增加与离婚状态和 COVID-19 期间睡眠不佳独立相关。
