Junior Resident, Department of Otorhinolaryngology-Head & Neck Surgery, AIIMS, New Delhi, India.
Associate Professor, Department of Otorhinolaryngology-Head & Neck Surgery, AIIMS, New Delhi, India.
J Vestib Res. 2021;31(6):433-440. doi: 10.3233/VES-201601.
Serum otolin-1 is an inner ear protein exclusively expressed in otoconia and cells of vestibule and cochlea. Serum otolin-1 is found to be quantifiable in patients with BPPV. Low Vitamin-D is associated with pathogenesis of BPPV. Since otoconia degeneration contributes to BPPV, lack of Vitamin-D may impact otoconia structure and integrity.
We aimed at studying the s.otolin-1 as biomarker and significance of vit-D in BPPV.
23 patients in test and control groups respectively were chosen within the age of 20 to 65 years. All the patients were diagnosed using Dix Hallpike menouver and head roll test, patients were treated with appropriate Canal Reposition Menouver (CRM).
Serum Otolin-1 levels among the test ranged from 366 to 882 pg/mL with mean of 585.17 pg/mL whereas in control group ranged from 223 to 462 pg/mL with mean of 335.26 pg/mL. Mean Vitamin-D levels among the test group was 22.67 ng/mL (Range = 6.3-68.4) and that of control 15.43 pg/mL (Range = 5.4-27.7) respectively. The relationship between the serum Otolin-1 and Vitamin-D was not statistically significant.
Otolin-1 levels is increased in BPPV patients and is sensitive in BPPV, specificity needs to be validated. Role of vitamin-D with respect to inner ear proteins needs further investigation.
血清 otolin-1 是一种仅在内耳耳石和前庭及耳蜗细胞中表达的内耳蛋白。已发现血清 otolin-1 在 BPPV 患者中可定量检测。低维生素-D 与 BPPV 的发病机制有关。由于耳石退化可导致 BPPV，缺乏维生素-D 可能会影响耳石的结构和完整性。
我们旨在研究 s.otolin-1 作为生物标志物以及维生素-D 在 BPPV 中的意义。
分别选择 23 名实验组和对照组患者，年龄在 20 至 65 岁之间。所有患者均通过 Dix-Hallpike 变位试验和头滚试验进行诊断，患者均接受适当的管石复位手法（CRM）治疗。
实验组血清 Otolin-1 水平为 366 至 882pg/mL，平均为 585.17pg/mL，而对照组为 223 至 462pg/mL，平均为 335.26pg/mL。实验组平均维生素-D 水平为 22.67ng/mL（范围=6.3-68.4），对照组为 15.43ng/mL（范围=5.4-27.7）。血清 Otolin-1 与维生素-D 之间的关系无统计学意义。
BPPV 患者血清 Otolin-1 水平升高，对 BPPV 敏感，特异性有待验证。维生素-D 与内耳蛋白的关系需要进一步研究。
