Geriatric Medicine and Gerontology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
J Alzheimers Dis. 2021;80(4):1583-1589. doi: 10.3233/JAD-201423.
The ongoing scientific debate regarding the association between physical function and cognitive impairment has focused mainly on global cognitive performance rather than specific cognitive functions tests and the importance of recognition of its associations and any factors that could play a role later in the prevention of such decline.
This study examined the association between physical function, using handgrip strength (HGS) and Timed Up-and-Go test (TUGT), and executive function (EF), using Clock Drawing Test (CDT), among community-dwelling Egyptian elderly.
A cross-sectional study was conducted in 5 social clubs in Cairo, Egypt and included a sample of 136 elderly males and females aged≥55 years old. All participants had their physical function assessed using TUGT, and measurement of HGS using a pneumatic hand-held dynamometer. Assessment of EF using CDT was also done.
Higher CDT scores were significantly associated with both better HGS, and lower TUGT (OR = 3.77, and 0.65 respectively). This persisted even after adjustment for age and gender (OR = 2.56, and 0.71 respectively) and after further adjustment for weight, systolic blood pressure, education, smoking, hyperlipidemia, hypothyroidism, and physical activity (O.R. = 4.79, and 0.76 respectively). Adjustment for both male and female genders showed an association between physical (HGS and TUGT) and EF was stronger among men.
A strong association between CDT score and both of HGS and TUGT was found among the studied sample. Higher HGS and lower TUGT was significantly associated with better performance in the CDT. This association is stronger in males than in females for both HGS and TUGT.
目前，科学界对于身体机能与认知障碍之间的关联仍存在争议，主要集中在整体认知表现上，而较少关注特定的认知功能测试，以及认识到这些关联以及任何可能在以后对预防认知下降起到作用的因素的重要性。
本研究旨在探讨握力（HGS）和计时起立行走测试（TUGT）等身体机能与执行功能（EF）（采用画钟测试（CDT））在埃及社区居住的老年人之间的关系。
本研究为横断面研究，在埃及开罗的 5 个社会俱乐部进行，共纳入 136 名年龄≥55 岁的男性和女性老年人。所有参与者均接受 TUGT 评估、使用气动手持测力计测量 HGS，还进行了 CDT 评估 EF。
更高的 CDT 评分与更好的 HGS 和更短的 TUGT 显著相关（比值比[OR]分别为 3.77 和 0.65）。这种相关性在调整年龄和性别后仍然存在（OR 分别为 2.56 和 0.71），并在进一步调整体重、收缩压、教育程度、吸烟、高脂血症、甲状腺功能减退症和身体活动后仍然存在（OR 分别为 4.79 和 0.76）。同时调整男性和女性的结果显示，在研究样本中，CDT 评分与 HGS 和 TUGT 之间存在很强的关联。HGS 越高和 TUGT 越低与 CDT 表现越好显著相关。这种关联在男性中比女性中更为明显，无论 HGS 还是 TUGT 都是如此。
在研究样本中，CDT 评分与 HGS 和 TUGT 之间存在很强的关联。HGS 越高和 TUGT 越低与 CDT 表现越好显著相关。这种关联在男性中比女性中更为明显，无论 HGS 还是 TUGT 都是如此。
