Ekofan Soğutma, Mugla, Turkey.
Hochschule Ruhr West, Institute for Measurement Engineering and Sensor Technology, Medical Informatics and Bioinformatics, Mülheim an der Ruhr, Germany.
J Integr Bioinform. 2021 Mar 16;18(1):19-26. doi: 10.1515/jib-2021-0001.
SARS-CoV-2 has spread worldwide and caused social, economic, and health turmoil. The first genome assembly of SARS-CoV-2 was produced in Wuhan, and it is widely used as a reference. Subsequently, more than a hundred additional SARS-CoV-2 genomes have been sequenced. While the genomes appear to be mostly identical, there are variations. Therefore, an alignment of all available genomes and the derived consensus sequence could be used as a reference, better serving the science community. Variations are significant, but representing them in a genome browser can become, especially if their sequences are largely identical. Here we summarize the variation in one track. Other information not currently found in genome browsers for SARS-CoV-2, such as predicted miRNAs and predicted TRS as well as secondary structure information, were also added as tracks to the consensus genome. We believe that a genome browser based on the consensus sequence is better suited when considering worldwide effects and can become a valuable resource in the combating of COVID-19. The genome browser is available at http://cov.iaba.online.
SARS-CoV-2 已在全球范围内传播，造成了社会、经济和健康方面的混乱。SARS-CoV-2 的第一个基因组组装是在武汉完成的，它被广泛用作参考。随后，又对一百多个 SARS-CoV-2 基因组进行了测序。尽管这些基因组似乎大多相同，但也存在一些变异。因此，对所有可用基因组进行比对并得出共识序列，可以作为一个参考，更好地为科学界服务。变异是显著的，但如果它们的序列大部分相同，在基因组浏览器中表示它们可能会变得复杂。在这里，我们总结了一个轨道中的变异情况。其他目前未在 SARS-CoV-2 基因组浏览器中找到的信息，如预测的 miRNA 和预测的 TRS 以及二级结构信息，也被作为轨道添加到共识基因组中。我们认为，基于共识序列的基因组浏览器在考虑全球影响时更合适，并可能成为抗击 COVID-19 的有价值资源。该基因组浏览器可在 http://cov.iaba.online 上获得。
