Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Microbiology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
J Biomater Appl. 2021 Oct;36(4):605-612. doi: 10.1177/08853282211003848. Epub 2021 Mar 15.
The aims of the present study were the determination of antimicrobial and antibiofilm effects of meropenem-loaded mesoporous silica nanoparticles (MSNs) on carbapenem resistant () and cytotoxicity properties . The meropenem-loaded MSNs had shown antibacterial and biofilm inhibitory activities on all isolates at different levels lower than MICs and BICs of meropenem. The viability of HC-04 cells treated with serial concentrations as MICs and BICs of meropenem-loaded MSNs was 92-100%. According to the obtained results, meropenem-loaded MSNs display the significant antibacterial and antibiofilm effects against carbapenem resistant and biofilm forming and low cell toxicity . Then, the prepared system can be an appropriate option for the delivery of carbapenem for further evaluation assays.
本研究的目的是确定载美罗培南介孔硅纳米粒子（MSNs）对耐碳青霉烯肠杆菌（）的抗菌和抗生物膜作用及其细胞毒性特性。载美罗培南的 MSNs 对所有分离株均显示出不同程度的抗菌和抗生物膜抑制活性，其浓度低于美罗培南的 MICs 和 BICs。用美罗培南载 MSNs 的 MICs 和 BICs 的连续浓度处理 HC-04 细胞的存活率为 92-100%。根据所得结果，载美罗培南 MSNs 对耐碳青霉烯和生物膜形成的肠杆菌表现出显著的抗菌和抗生物膜作用，且细胞毒性低。因此，该制备系统可以作为进一步评估碳青霉烯类药物输送的合适选择。
