Maleki Dizaj Solmaz, Sharifi Simin, Tavakoli Fatemeh, Hussain Yaseen, Forouhandeh Haleh, Hosseiniyan Khatibi Seyed Mahdi, Memar Mohammad Yousef, Yekani Mina, Khan Haroon, Goh Khang Wen, Ming Long Chiau
Department of Dental Biomaterials, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz 5165665931, Iran.
Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz 5165665931, Iran.
Nanomaterials (Basel). 2022 Aug 18;12(16):2848. doi: 10.3390/nano12162848.
Curcumin has multiple properties that are used to cure different diseases such as cancer, infections, inflammatory, arthritic disease, etc. Despite having many effects, the inherent physicochemical properties-such as poor water solubility, chemical instability, low bioavailability, photodegradation, fast metabolism, and short half-life-of curcumin's derivatives have limited its medical importance. Recently, unprecedented advances in biomedical nanotechnology have led to the development of nanomaterial-based drug delivery systems in the treatment of diseases and diagnostic goals that simultaneously enhance therapeutic outcomes and avoid side effects. Mesoporous silica nanoparticles (MSNs) are promising drug delivery systems for more effective and safer treatment of several diseases, such as infections, cancers, and osteoporosis. Achieving a high drug loading in MSNs is critical to the success of this type of treatment. Their notable inherent properties-such as adjustable size and porosity, high pore volume, large surface area, functionality of versatile surfaces, as well as biocompatibility-have prompted extraordinary research on MSNs as multi-purpose delivery platforms. In this review, we focused on curcumin-loaded silica nanoparticles and their effects on the diagnosis and treatment of infections as well as their use in food packaging.
姜黄素具有多种特性，可用于治疗不同疾病，如癌症、感染、炎症性疾病、关节炎等。尽管姜黄素具有多种功效，但其衍生物固有的物理化学性质，如低水溶性、化学不稳定性、低生物利用度、光降解、快速代谢和短半衰期等，限制了其医学应用价值。近年来，生物医学纳米技术取得了前所未有的进展，推动了基于纳米材料的药物递送系统的发展，用于疾病治疗和诊断，同时提高治疗效果并避免副作用。介孔二氧化硅纳米颗粒（MSNs）是一种很有前景的药物递送系统，可更有效、更安全地治疗多种疾病，如感染、癌症和骨质疏松症。在MSNs中实现高药物负载量对于这类治疗的成功至关重要。它们显著的固有特性，如可调节的尺寸和孔隙率、高孔体积、大表面积、多功能表面的功能性以及生物相容性，促使人们对MSNs作为多功能递送平台进行了大量研究。在这篇综述中，我们重点关注了负载姜黄素的二氧化硅纳米颗粒及其对感染诊断和治疗的影响，以及它们在食品包装中的应用。
