National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, USA; RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute (NCI), NIH, Frederick, MD 21702, USA.
RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute (NCI), NIH, Frederick, MD 21702, USA.
Trends Mol Med. 2021 May;27(5):422-435. doi: 10.1016/j.molmed.2021.02.003. Epub 2021 Mar 12.
Although autoimmunity and autoimmune disease (AID) are relatively common, the repertoire of autoantigens is paradoxically very limited. Highly enriched in this autoantigen repertoire are nucleic acids and their binding proteins, which together form large macromolecular structures. Most of these complexes are of ancient evolutionary origin, with homologs throughout multiple kingdoms of life. Why and if these nucleic acid-protein particles drive the development of autoimmunity remains unresolved. Recent advances in our understanding of the microbiome may provide clues about the origins of autoimmunity - and the particular puzzle of why the autoantigen repertoire is so particularly enriched in ribonucleoprotein particles (RNPs). We discuss the possibility that autoimmunity to some RNPs may arise from molecular mimicry to microbial orthologs.
虽然自身免疫和自身免疫性疾病（AID）相对常见，但自身抗原的范围实际上非常有限。在自身抗原谱中高度富集的是核酸及其结合蛋白，它们共同形成大型大分子结构。这些复合物大多数具有古老的进化起源，在生命的多个王国中都有同源物。为什么以及是否这些核酸-蛋白质颗粒会引发自身免疫仍然没有解决。我们对微生物组的理解的最新进展可能为自身免疫的起源提供线索-以及为什么自身抗原谱特别富含核糖核蛋白颗粒（RNP）的特殊难题。我们讨论了某些 RNP 的自身免疫可能源于与微生物同源物的分子模拟的可能性。
