雾化米卡芬净治疗肺移植受者的气管支气管炎。
Nebulized Micafungin Treatment for / Tracheobronchitis in Lung Transplant Recipients.
机构信息
Infectious Diseases Department, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
Lung Transplant Unit, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
出版信息
Antimicrob Agents Chemother. 2021 May 18;65(6). doi: 10.1128/AAC.02174-20.
Abstract
/ isolates cause infections with high mortality in lung transplant recipients. Treatment is challenging due to antimicrobial resistance. We describe two cases of / tracheobronchitis in lung transplant recipients successfully treated with nebulized micafungin. This antifungal was well tolerated and achieved high concentrations in epithelial lining fluid up to 14 h after nebulization without significant plasma concentrations. Nebulized micafungin may be a safe and effective option for the treatment of fungal tracheobronchitis.
摘要
/ 分离株可导致肺移植受者发生高死亡率感染。由于存在抗菌药物耐药性，治疗具有挑战性。我们描述了两例肺移植受者 / 支气管肺炎，成功地使用雾化米卡芬净进行了治疗。这种抗真菌药物耐受性良好，在雾化后 14 小时上皮衬里液中可达到高浓度，而无明显的血浆浓度。雾化米卡芬净可能是治疗真菌性气管支气管炎的一种安全有效的选择。
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2
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3
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4
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