体外抗真菌药物三联疗法治疗临床帚霉属和皮壳霉属物种。
In Vitro Triple Combination of Antifungal Drugs against Clinical Scopulariopsis and Microascus Species.
机构信息
Department of Dermatology and Venereology, Peking University First Hospital, Research Center for Medical Mycology, Peking University, Beijing, China Beijing Key Laboratory of Molecular Diagnosis of Dermatoses, Beijing, China.
Department of Dermatology and Venereology, Peking University First Hospital, Research Center for Medical Mycology, Peking University, Beijing, China Beijing Key Laboratory of Molecular Diagnosis of Dermatoses, Beijing, China
出版信息
Antimicrob Agents Chemother. 2015 Aug;59(8):5040-3. doi: 10.1128/AAC.00145-15. Epub 2015 May 26.
Abstract
Broth microdilution checkerboard techniques based on the methodology of the Clinical and Laboratory Standards Institute (CLSI) were employed to study the triple antifungal combination of caspofungin, posaconazole, and terbinafine against 27 clinical isolates of Scopulariopsis and Microascus species. Synergy was observed for 26 isolates, whereas antagonism was observed for Scopulariopsis candida in this study.
摘要
采用基于临床和实验室标准协会（CLSI）方法学的肉汤微量稀释棋盘技术，研究了卡泊芬净、泊沙康唑和特比萘芬三联抗真菌组合对 27 株链格孢属和皮壳科菌属临床分离株的作用。本研究观察到 26 株分离株表现协同作用，而对链格孢属的构巢曲霉则表现拮抗作用。
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