Pérez-Cantero Alba, Guarro Josep
Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili and Institut d'Investigació Sanitària Pere Virgili (IISPV). Reus, Tarragona, Spain.
Med Mycol. 2020 Feb 1;58(2):145-155. doi: 10.1093/mmy/myz036.
Scopulariopsis is a common fungus in the environment, characterized by its intrinsic resistance to the available antifungal drugs. Around 70 cases of infection by this fungus have been described in the literature. Pulmonary and disseminated infections are the most common and their treatment is difficult; therefore, very diverse approaches have been taken, with varied results. A successful outcome has been reported in only a few cases, generally attributed to a multitreatment strategy combining medical and surgical procedures that ultimately led to the resection of the infected tissue if possible, identification of the mould, and an aggressive long-term antifungal therapy. Although most of the infections are caused by Scopulariopsis brevicaulis, a few other species have also been linked to these cases, although molecular evidence has not been proven for all of them. On this basis, more knowledge on the epidemiology, presentation, diagnosis, treatment, and prognosis of these unusual infections would improve their management. This review aims to compile the current data on Scopulariopsis infections.
帚霉是环境中常见的真菌，其特点是对现有抗真菌药物具有固有抗性。文献中已描述了约70例由这种真菌引起的感染病例。肺部感染和播散性感染最为常见，且治疗困难；因此，人们采取了非常多样的方法，但结果各异。仅在少数病例中报告了成功的治疗结果，通常归因于一种多学科治疗策略，该策略结合了内科和外科手术，最终尽可能切除感染组织、鉴定霉菌并进行积极的长期抗真菌治疗。虽然大多数感染是由短帚霉引起的，但也有其他一些菌种与这些病例有关，尽管并非所有病例都有分子证据支持。在此基础上，更多地了解这些罕见感染的流行病学、临床表现、诊断、治疗和预后将有助于改善对它们的管理。本综述旨在汇总关于帚霉感染的现有数据。
