Department of Clinical Laboratory, Peking University People's Hospital, Beijing, China.
Department of Clinical Laboratory, Peking University People's Hospital, Beijing, China
Antimicrob Agents Chemother. 2021 May 18;65(6). doi: 10.1128/AAC.02435-20.
Recent emergence of carbapenem-resistant (CRKP) coharboring and pLVPK-like virulence plasmids represented a novel clinical challenge. In the present study, we characterized a and virulence hybrid plasmid, designated pCRHV-C2244, from a clinical ST11-K64 CRKP strain. pCRHV-C2244 was non-self-transmissible due to incomplete conjugative elements but mobilizable together with a conjugative helper. Enhanced virulence and stable maintenance without significant fitness loss in its original host were confirmed and .
最近出现的碳青霉烯类耐药（CRKP）同时携带 和 pLVPK 样毒力质粒代表了一种新的临床挑战。在本研究中，我们从临床 ST11-K64 CRKP 菌株中鉴定了一个 和毒力混合质粒，命名为 pCRHV-C2244。由于不完全的接合元件，pCRHV-C2244 是非自我传递的，但可以与一个接合辅助质粒一起移动。在其原始宿主中，增强的毒力和稳定的维持而没有明显的适应性损失得到了确认。
