肺炎克雷伯菌 11 型中携带 KPC-2 及毒力因子的新型混合质粒的鉴定
Identification of a Novel Hybrid Plasmid Encoding KPC-2 and Virulence Factors in Klebsiella pneumoniae Sequence Type 11.
机构信息
Department of Clinical Laboratory, Peking University People's Hospital, Beijing, China.
Department of Clinical Laboratory, Peking University People's Hospital, Beijing, China
出版信息
Antimicrob Agents Chemother. 2021 May 18;65(6). doi: 10.1128/AAC.02435-20.
Abstract
Recent emergence of carbapenem-resistant (CRKP) coharboring and pLVPK-like virulence plasmids represented a novel clinical challenge. In the present study, we characterized a and virulence hybrid plasmid, designated pCRHV-C2244, from a clinical ST11-K64 CRKP strain. pCRHV-C2244 was non-self-transmissible due to incomplete conjugative elements but mobilizable together with a conjugative helper. Enhanced virulence and stable maintenance without significant fitness loss in its original host were confirmed and .
摘要
最近出现的碳青霉烯类耐药（CRKP）同时携带 和 pLVPK 样毒力质粒代表了一种新的临床挑战。在本研究中，我们从临床 ST11-K64 CRKP 菌株中鉴定了一个 和毒力混合质粒，命名为 pCRHV-C2244。由于不完全的接合元件，pCRHV-C2244 是非自我传递的，但可以与一个接合辅助质粒一起移动。在其原始宿主中，增强的毒力和稳定的维持而没有明显的适应性损失得到了确认。
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