Department of Ophthalmology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 10, 63-ro, Yeongdeungpo-gu, Seoul, 07345, Republic of Korea.
Department of Statistics and Actuarial Science, Soongsil University, Seoul, Republic of Korea.
Sci Rep. 2021 Mar 15;11(1):5888. doi: 10.1038/s41598-021-85380-6.
Although depression and glaucoma share several common pathophysiology, the risk of glaucoma in patients with depression has not been reported. Thus, we investigated the effect of depressive symptom and depressive disorder on glaucoma incidence. In this nationwide population-based cohort study, all subjects receiving the National Screening Program at the age of 66 during 2009-2014 were included. These subjects were divided into depression group and no depression group based on subjective depressive symptoms and clinically diagnosed depressive disorder and were tracked until 2017 for development of glaucoma. Of the 922,769 subjects included in the study, 191,636 (20.77%) subjects were categorized as depression group. Subjects with depression showed increased hazard of developing glaucoma (adjusted HR = 1.12[95% confidence interval (CI), 1.09-1.15]) than those without depression. The risk of glaucoma increased sequentially from those with no depression to those with subjective depressive symptom (adjusted HR = 1.09[95% CI, 1.06-1.13]), those with clinically diagnosed depressive disorder (adjusted HR = 1.23[95% CI, 1.14-1.32]), and those with both subjective depressive symptom and clinically diagnosed depressive disorder (adjusted HR = 1.36[95% CI, 1.22-1.52]). Our analyses suggest that individuals with depression had a greater risk of developing glaucoma than those without depression. Subjective depressive symptoms and clinically diagnosed depressive disorder independently and synergistically increased the risk of glaucoma incidence.
虽然抑郁和青光眼有一些共同的病理生理学，但抑郁患者患青光眼的风险尚未被报道。因此，我们研究了抑郁症状和抑郁障碍对青光眼发病的影响。在这项全国性基于人群的队列研究中，纳入了所有在 2009-2014 年期间接受 66 岁国家筛查计划的受试者。这些受试者根据主观抑郁症状和临床诊断的抑郁障碍分为抑郁组和非抑郁组，并随访至 2017 年，以观察青光眼的发生。在研究的 922769 名受试者中，191636 名（20.77%）受试者被归类为抑郁组。与无抑郁的受试者相比，有抑郁的受试者发生青光眼的风险增加（调整后的 HR=1.12[95%可信区间（CI），1.09-1.15]）。从无抑郁到有主观抑郁症状（调整后的 HR=1.09[95%CI，1.06-1.13]）、有临床诊断的抑郁障碍（调整后的 HR=1.23[95%CI，1.14-1.32]）和同时有主观抑郁症状和临床诊断的抑郁障碍（调整后的 HR=1.36[95%CI，1.22-1.52]），青光眼的风险依次增加。我们的分析表明，抑郁患者发生青光眼的风险高于无抑郁患者。主观抑郁症状和临床诊断的抑郁障碍独立且协同地增加了青光眼发病的风险。
